Cardiovascular effects of an ionophorous antibiotic, lonomycin A, in anesthetized dogs.
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概要
- 論文の詳細を見る
An intracoronary administration of lonomycin A, a K-selective ionophore, produced coronary vasodilatation in the presence of pindolol in anesthetized dogs. Coronary vasodilatation induced by lonomycin A, KCl and nifedipine was inhibited by pretreatment with an intracoronary injection of ouabain. This result suggests that lonomycin A-induced coronary vasodilatation may be partly due to a stimulation of Na<SUP>+</SUP>, K<SUP>+</SUP>-ATPase as well as KCl and/or a decrease in Ca<SUP>2+</SUP> influx as well as nifedipine.
- 公益社団法人 日本薬理学会の論文
著者
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Aihara Hironaka
Research Center Taisho Pharmaceutical Co. Ltd.
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Tsuchida Katsuharu
Research Center Taisho Pharmaceutical Co. Ltd.
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KANEKO KATSUYOSHI
Research Center, Taisho Pharmaceutical Co., Ltd.
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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AIHARA Hironaka
Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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KANEKO Katsuyoshi
Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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