Uptake of CD-349 and Nitrendipine into Bovine Intrapulmonary Artery and Vein
スポンサーリンク
概要
- 論文の詳細を見る
The uptake of CD-349 into the bovine intrapulmonary artery (BPA) and vein (BPV) was examined and characteristics of this newly synthesized 1,4-dihydropyridine Ca^<2+> antagonist were compared with those of nitrendipine. One hundred minutes after initiation of incubation of the vessels, the uptake of [^3H] CD-349 and [^3H] nitrendipine reached a plateau. The concentrations of CD-349 inside the muscle cell of the BPA and BPV were 11.1 and 6.8 times higher than that of the incubation medium, respectively, and concentrations of nitrendipine in the BPA and BPV were 8.6 and 6.1 times higher, respectively. The degree of uptake was not influenced by the lowering the incubation temperature nor by adding 2,4-dinitrophenol. The partition coefficient of CD-349 measured in the corn oil/Ringer and octanol/Ringer systems was greater than the partition coefficient of nitrendipine, independent of the concentration tested. These results suggest that CD-349 permeates smooth muscle membrane by passive diffusion and accumulates inside the muscle cells, much in the same manner as seen with nitrendipine. The lipid solubility of DC-349 presumably accounts for these events.
- 公益社団法人日本薬学会の論文
著者
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MURAMATSU Makoto
Institute of Applied Physics, University of Tsukuba
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MURAMATSU Makoto
National Institute of Advanced Industrial Science and Technology (AIST)
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TANAKA MAKOTO
Research Center, Taisho Pharmaceutical Co., Ltd.
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AIHARA Hironaka
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co., Ltd.
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Aihara H
Department Of Pharmacology Research Center Taisho Pharmaceutical Co. Ltd.
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Aihara Hironaka
Research Center Taisho Pharmaceutical Co. Ltd.
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Muramatsu Makoto
Research Center Taisho Pharmaceutical Co. Ltd.
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Tanaka M
Kanagawa Laboratories Bristol-myers Squibb K.k.
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Muramatsu M
Institute Of Applied Physics University Of Tsukuba
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TANAKA Makoto
Research Center, Taisho Pharmaceutical Co., Ltd
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