EFFECTS OF MORPHINE AND INDOMETHACIN ON EVOKED NEURONAL RESPONSES OF VENTROBASAL THALAMIC NEURONES : SITE OF ACTION OF ANALGESIC DRUGS IN NONADJUVANT ARTHRITIC RATS

概要

論文の詳細を見る
Single neuronal activity was recorded extracellularly in the ventrobasal (VB) nucleus of the thalamus in non-adjuvant arthritic rats under urethane (1200mg/kg, i.p.) anesthesia. The effects of morphine and indomethacin on the evoked responses elicited by noxious stimuli such as transcutaneous electrical stimulation (TES) or tibial nerve electrical stimulation (TNES), or non-noxious stimulation such as repetitive brushing were examined. Intravenous administered morphine (0.1,0.3 and 1mg/kg) depressed the evoked responses elicited by either TES or TNES without affecting any background activities. In contrast, intravenous administered indomethacin (1,3 and 10mg/kg) depressed the evoked responses induced by TES, but failed to depress the evoked responses induced by TNES. At doses of 3 and 10mg/kg, indomethacin slightly depressed the background activities of the nociceptive neurones. Depressant effects of morphine were restored by intravenous naloxone (0.5 mg/kg) administration, but not observed in case of indomethacin. The evoked responses induced by non-noxious stimulation failed to depress either indomethacin or morphine administration. These results suggest that the site of action of indomethacin in non-adjuvant arthritic rats is mainly in the periphery. In contrast, morphine produced an antinociceptic action due to the central mechanism.
公益社団法人日本薬学会の論文