EFFECTS OF PROPRANOLOL ON TISSUE NECROSIS IN EXPERIMENTAL MYOCARDIAL INFARCTION IN DOGS
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概要
- 論文の詳細を見る
We studied the effects of propranolol on degradation of cardiac structural proteins resulting from ischemia induced by 24 h ligation of the coronary artery in dogs. Degradation of myocardial myosin heavy chain, α-actinin and troponin-I was used as an indicator of degradation of cardiac structural proteins. In dogs with left circumflex coronary artery ligation, propranolol, given orally in the dose of 10 or 30 mg/kg, significantly reduced degradation of cardiac structural proteins. This can be supported by the facts that treatment with propranolol, 10 or 30 mg/kg, reduced release of cathepsins B, L and D from lysosome to cytosol in the ischemic tissue and that the reduced acidity of the ischemic tissue was improved by treatment with propranolol, 30 mg/kg. In conclusion, propranlol delays the necrotic development of the severely ischemic myocardial tissue as shown by reduced protein degradation.
- 公益社団法人日本薬学会の論文
著者
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KANEKO Ko
Faculty of Pharamaceutical Sciences, Hokkaido University
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Kaneko Ko
Faculty Of Pharamaceutical Sciences Hokkaido University
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AIHARA Hironaka
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co., Ltd.
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Aihara H
Department Of Pharmacology Research Center Taisho Pharmaceutical Co. Ltd.
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Aihara Hironaka
Research Center Taisho Pharmaceutical Co. Ltd.
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TSUCHIDA Katsuharu
Research Center, Taisho Pharmaceutical Co., Ltd.
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Yamazaki R
Research Center Taisho Pharmaceutical Co. Ltd.
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Yamazaki Ryuzaburo
Research Center Taisho Pharmaceutical Company Ltd.
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Tsuchida Katsuharu
Research Center Taisho Pharmaceutical Co. Ltd.
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KANEKO KATSUYOSHI
Research Center, Taisho Pharmaceutical Co., Ltd.
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