THE ROLE OF NORADRENERGIC AND SEROTONERGIC SYSTEMS IN THE HIPPOCAMPAL KINDLING EFFECT
スポンサーリンク
概要
- 論文の詳細を見る
The role of the noradrenergic and the serotonergic systems in the development of hippocampal and amygdaloid kindling was studied. Dorsal noradrenaline bundle lesions markedly facilitated the formation of hippocampal and amygdaloid kindling. The most significant facilitation was observed in the earliest phase of kindling. Cortical noradrenaline content decreased by about 70% after dorsal noradrenaline bundle lesions. Midbrain raphe nuclei (both dorsal and medial raphe nuclei) lesions did not have any effect on the formation of both hippocampal and amygdaloid kindling. These results indicate that the dorsal noradrenaline bundle system plays an inhibitory role in the development of the seizure discharges and the behavioral convulsions in hippocampal and amygdaloid kindling.
- 社団法人 日本薬理学会の論文
著者
-
Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
-
Ueki Showa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
-
Ohta Hisashi
Department Of Electronics Engineering Shibaura Institute Of Technology
-
AIHARA Hironaka
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co., Ltd.
-
Yamamoto Tsuneyuki
Department Of Developmental Biology Of Hard Tissue Graduate School Of Dental Medicine Hokkaido Unive
-
Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
-
AIHARA Hironaka
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co. Ltd.
-
AIHARA Hironaka
Department of Pharmacology, Research Laboratories, Taisho Pharmaceutical Co., Ltd.
-
AIHARA Hironaka
Department of Pharmacology, Research Center, Taisho Pharamceutical Co., Ltd.
-
UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
関連論文
- New Perspectives in the Studies on Endocannabinoid and Cannabis : A Role for the Endocannabinoid-Arachidonic Acid Pathway in Drug Reward and Long-Lasting Relapse to Drug Taking
- The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats
- The Coadministration of Paroxetine and Low-Dose Aspirin Synergistically Enhances Gastric Ulcerogenic Risk in Rats(Pharmacology)
- Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method
- Effects of Repeated Electroconvulsive Seizures on Spontaneous Alternation Behavior and Locomotor Activity in Rats(Pharmacology)
- Comparison of Short- and Long-Acting Benzodiazepine-Receptor Agonists With Different Receptor Selectivity on Motor Coordination and Muscle Relaxation Following Thiopental-Induced Anesthesia in Mice
- Effect of Aripiprazole on 5-HT_2 Receptor-mediated Wet-Dog Shake Responses and Disruption of Prepulse Inhibition in Rats
- Effect of Simultaneous Insertion of Oleaginous Base on the Absorption and on the Anticonvulsant Effect of Diazepam Suppository(Pharmacology)
- Effect of Methamphetamine and Imipramine on Cerebral Ischemia-Induced Hyperactivity in Mongolian Gerbils
- Counseling of Patients with Bronchial Asthma, and Clinical Pharmacy Practice and Education of Pharmacy School Students
- FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line
- Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats
- Systemic Effects of Carteolol, a β-Adrenoceptor Antagonist in Stroke-Prone Spontaneously Hypertensive Rats
- Effect of Diazepam on the Runway Method Using Priming Stimulation of Intracranial Self Stimulation Behavior
- The 5-HT_ Receptor Full Agonist, 8-OH-DPAT Inhibits ACTH-Induced 5-HT_ Receptor Hyperfunction in Rats : Involvement of 5-HT_ Receptors in the DOI-Induced Wet-Dog Shakes in ACTH-Treated Rats(Pharmacology)
- Activation of Cerebral Function by CS-932, a Functionally Selective M_1 Partial Agonist : Neurochemical Characterization and Pharmacological Studies
- Time-Dependent Effect of Glutamate on Long-Term Potentiation in the Suprachiasmatic Nucleus of Rats
- Both Metabotropic Glutamate I and II Receptors Mediate Augmentation of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats
- Neuronal Nicoticic Receptor and Psychiatric Disorders: Functional and Behavioral Effects of Nicotine
- Motivational Effect of Nomifensine in the Intracranial Self-Stimulation Behavior Using a Runway Method(Pharmacology)
- Motivational Effects of Methamphetamine as Measured by the Runway Method Using Priming Stimulation of Intracranial Self-stimulation Behavior(Analytical Biochemistry)
- Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats
- Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve Function in the Mesenteric Artery of Spontaneously Hyupertensive Rats
- Long-Term Treatment With Angiotensin Converting Enzyme Inhibitor Restores Reduced Calcitonin Gene-Related Peptide-Containing Vasodilator Nerve Function in Mesenteric Artery of Spontaneously Hypertensive Rats
- CHANGES IN CIRCADIAN RHYTHM OF LOCOMOTOR ACTIVITY INDUCED BY CEREBRAL ISCHEMIA IN MONGOLIAN GERBILS
- Involvement of the Medial Amygdaloid Nucleus in the Action of Imipramine in Rats Subjected to the Forced Swimming Test
- A NEW FORCED SWIMMING TEST FOR THE EVALUATION OF ANTIDEPRESSANTS IN RATS BY RECORDING VIBRATION OF A WATER TANK
- Detrimental Role of Corticotropin-Releasing Factor on the Decrease of CA1 Field Potential Induced by In Vitro Ischemia in Rat Hippocampal Slices
- Hematological Change in Venous Blood of the Lower Leg during Prolonged Sitting in a Low Humidity and Hypobaric Environment
- Effect of TTC-909 on Cerebral Infarction Following Permanent Occlusion of the Middle Cerebral Artery in Stroke Prone Spontaneously Hypertensive Rats
- EFFECTS OF LIMBIC LESIONS, ESPECIALLY OF OLFACTORY BULBECTOMY ON SIMPLE CONDITIONED AVOIDANCE RESPONSE IN RATS
- INHIBITION OF PROSTAGLANDIN BIOSYNTHESIS BY A NEW ANTIINFLAMMATORY DRUG, TA-60
- Effect of Heat Exposure on Aminophylline-Induced Convulsions in Mice
- Selective M3 Muscarinic Receptor Antagonist Inhibits Small-Cell Lung Carcinoma Growth in a Mouse Orthotopic Xenograft Model
- Role of Cannabinoid Receptor in the Brain as It Relates to Drug Reward
- ATTENUATION OF SEROTONIN-SUPPRESSED [^3H] ACETYLCHOLINE RELEASE FROM RAT HIPPOCAMPUS BY MINAPRINE : INVOLVEMENT OF 5-HT_2 RECEPTOR AND VOLTAGE-DEPENDENT K^+ CHANNEL
- New Perspectives in the Studies on Endocannabinoid and Cannabis : Preface
- Bimaxillary Ameloblastoma : case report
- Apparatus for Electrical Measurement of the Resistive Force on a Wheel Rolling on Soft and Uneven Grounds
- PHARMACOLOGICAL CHARACTERISTICS OF ABNORMAL BEHAVIOR INDUCED BY HARMINE WITH SPECIAL REFERENCE TO TREMOR IN MICE
- Ultrastructural Assessment of Mineral Crystallization and Collagen Mineralization in Bone
- A Key Role of the Mammillary Body in Mediation of the Antianxiety Action of Zopiclone, a Cyclopyrrolone Derivative
- Effect of TTC-909 on Cerebral Infarction Following Permanent Occlusion of the Middle Cerebral Artery in Stroke Prone Spontaneously Hypertensive Rats
- THE EFFECT OF AGE ON THE DEVELOPMENT OF HYPEREMOTIONALITY FOLLOWING BILATERAL OLFACTORY BULBECTOMY IN RATS
- THE ROLE OF NORADRENERGIC AND SEROTONERGIC SYSTEMS IN THE HIPPOCAMPAL KINDLING EFFECT
- EFFECTS OF RESERPINE, α-METHYL-p-TYROSINE, P-CHLOROPHENYLALANINE AND 5, 7-DIHYDROXYTRYPTAMINE ON THE HIPPOCAMPAL KINDLING EFFECT IN RATS
- HIPPOCAMPAL KINDLING AND EFFECTS OF ANTIEPILEPTIC DRUGS
- EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL ON THE CARDIOVASCULAR SYSTEM, AND PRESSOR AND BEHAVIORAL RESPONSES TO BRAIN STIMULATION IN RATS
- CARDIOVASCULAR CHANGES INDUCED BY LARGE DOSES OF CLONIDINE IN MICE
- Uptake of CD-349 and Nitrendipine into Bovine Intrapulmonary Artery and Vein
- EFFECTS OF PROPRANOLOL ON TISSUE NECROSIS IN EXPERIMENTAL MYOCARDIAL INFARCTION IN DOGS
- EFFECTS OF PROPRANOLOL ON INFARCT SIZE AND THE IMPAIRED HEMODYNAMICS IN EXPERIMENTAL MYOCARDIAL INFARCTED DOGS
- Behavioral and Electroencephalographic Effects of a Depot Type Neuroleptic Fluphenazine Decanoate, in Rats
- EFFECT OF ZOTEPINE ON HEAD-TWITCH INDUCED BY L-5-HYDROXYTRYPTOPHAN, MESCALINE AND 2, 5-DIMETHOXY-4-METHYLAMPHETAMINE IN MICE AND RATS
- EFFECTS OF LOCUS COERULEUS STIMULATION ON MURICIDE IN OLFACTORY BULBECTOMIZED AND RAPHE LESIONED RATS
- EFFECT OF AMINO ACIDS AND MONOAMINES ON THE NEURONAL ACTIVITY OF SUPRACHIASMATIC NUCLEUS IN HYPOTHALAMIC SLICE PREPARATIONS
- EFFECTS OF PSYCHOTROPIC DRUGS INJECTED INTO THE LIMBIC STRUCTURES ON MOUSE-KILLING BEHAVIOR IN THE RAT WITH OLFACTORY BULB ABLATIONS
- PHARMACOLOGICAL STUDIES OF FURO [3,2-b] INDOLE DERIVATIVES. II. ANALGESIC EFFECT OF FI-302,N-(3-PIPER-IDINOPROPYL)-4-METHYL-6-TRIFLUOROMETHYL-FURO [3,2-b] INDOLE-2-CARBOXAMIDE, IN EXPERIMENTAL ANIMALS
- PHARMACOLOGICAL STUDIES OF FURO [3,2-b] INDOLE DERIVATIVES. I. ANALGESIC, ANTI-PYRETIC AND ANTI-INLAMMATORY EFFECTS OF FI-302,N-(3-PIPERIDINOPROPYL)-4-METHYL-6-TRIFLUOROMETHYL-FURO [3,2-b] INDOLE-2-CARBOXAMIDE, IN EXPERIMENTAL ANIMALS
- EFFECTS OF ELECTROCONVULSIVE SHOCK ON MOUSE-KILLING BEHAVIOR (MURICIDE) IN OLFACTORY BULBECTOMIZED RATS
- EFFECT OF DESIPRAMINE ON NORADRENERGIC INHIBITION OF AMYGDALOID EVOKED POTENTIAL
- EFFECT OF STIMULATION OF LOCUS COERULEUS ON THE EVOKED POTENTIAL IN THE AMYGDALA IN RATS
- INFLUENCE OF AGGREGATION ON THE ACTION OF METHAMPHETAMINE IN LOCOMOTOR ACTIVITY
- Histological review of the human cellular cementum with special reference to an alternating lamellar pattern
- POSSIBLE INVOLVEMENT OF A CENTRAL NORADRENERGIC SYSTEM IN AUTOMUTILATION INDUCED BY CLONIDINE IN MICE
- CHANGES IN SENSITIVITY OF MICE TO ANTICONVULSANT DRUGS FOLLOWING BILATERAL OLFACTORY BULB ABLATIONS
- EFFECTS OF MONOAMINES INJECTED INTO THE HIPPOCAMPUS ON HIPPOCAMPAL SEIZURE DISCHARGES IN THE RABBIT
- EFFECT OF MEDIAN RAPHE STIMULATION ON HIPPOCAMPAL SEIZURE DISCHARGE INDUCED BY CARBACHOL IN THE RABBIT
- CHANGES IN SENSITIVITY TO CONVULSION IN MICE WITH OLFACTORY BULB ABLATION
- SIGNIFICANCE OF WITHDRAWAL JUMPING RESPONSE IN PREDICTING PHYSICAL DEPENDENCE IN MICE
- Nitrooxy Alkyl Apovincaminate Activates K^+ Currents in Rat Neocortical Neurons
- NALOXONE-INDUCED ABSTINENCE SYNDROMES IN MORPHINE-TREATED MICE
- Bone-Orchestrating Cells, Osteocytes
- Selective M_3 Muscarinic Receptor Antagonist Inhibits Small-Cell Lung Carcinoma Growth in a Mouse Orthotopic Xenograft Model
- EFFECTS OF PSYCHOTROPIC DRUGS ON HYPEREMOTION-ALITY OF RATS WITH BILATERAL ABLATIONS OF THE OLFACTORY BULBS AND OLFACTORY TUBERCLES
- HYPEREMOTIONALITY INDUCED BY LESIONS IN THE OLFACTORY SYSTEM OF THE RAT
- A New Method for Studying Working Memory by Using the Three-Panel Runway Apparatus in Rats
- Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
- Bone-Orchestrating Cells, Osteocytes
- Impairment of memory and changes in neurotransmitters induced by basal forebrain lesion in rats.
- Behavioral analysis of zopiclone on the basis of their discriminative stimulus properties in the rat.
- Evaluation of the neuroprotective action of WEB 1881 FU on hypoglycemia/hypoxia-induced neuronal damage using rat striatal slices.
- Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative.
- Inhibitory effects of condensed tannins on angiotensin converting enzyme.
- A Test–Retest Paradigm of the Forced Swimming Test in Female Mice Is not Valid for Predicting Antidepressant-Like Activity: Participation of Acetylcholine and Sigma-1 Receptors
- .BETA.-CCM inhibits muricide induced by olfactory bulbectomy in rats.
- WEB 1881 FU ameliorates impairement of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task.
- Changes in monoamine contents in the brains of Mongolian gerbils following a 5-min occlusion of the bilateral carotid arteries.
- Role of the amygdala in the hippocampal kindling effect of rats.
- Effects of a K ionophore, lonomycin A, on the action potential in canine cardiac Purkinje fibers.
- Effect of minaprine on changes in monoamine contents in Mongolian gerbils with 5-min occlusion of common carotid arteries.
- Effect of minaprine and other reference drugs on passive avoidance impairment induced by cerebral ischemia in Mongolian gerbils.
- Nootropic Candidates Inhibit Head-Twitches Induced by Mescaline in Mice.
- Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative.
- The effect of agonists at the GABA-benzodiazepine-receptor-complex on the proconflict effect induced by .BETA.-CCM and pentetrazol in rats.
- Effect of chronic administration of antidepressants on duration of immobility in rats forced to swim.
- The effect of a selective phosphodiesterase inhibitor, rolipram, on muricide in olfactory bulbectomized rats.
- Decreased density of rat atrial natriuretic polypeptide binding sites in brain capillaries of spontaneously hypertensive rats
- Morphological aspects of the biological function of the osteocytic lacunar canalicular system and of osteocyte-derived factors
- The chronic effect of bunitrolol on blood pressure and plasma catecholamines in spontaneously hypertensive rats