Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve Function in the Mesenteric Artery of Spontaneously Hyupertensive Rats
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概要
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The effect of long−term treatment with dihydropyridine calcium antagonists(amlodipine, pranidipine, nicardipine)on the periarterial nerve function was investigated in the perfused mesenteric vascular bed isolated from spontaneously hypertensive rat(SHR).Male 8−week−old SHR received amlodipine(0.01% and 0.02%)and nicardipine(0.1%)in drinking water and pranidipine(0.0035% and 0.035%)in rat chow for 7 weeks.Mean blood pressure in SHR was significantly lowered by long−term treatment with each calcium antagonist.In mesenteric vascular preparations treated with each calcium antagonist, vasoconstriction induced by periarterial nerve stimulation(PNS;4, 8 and 12 Hz)was significantly smaller than that in non−treated SHR.The PNS(8 Hz)−evoked norepinephrine(NE)overflow in the perfusate was significantly decreased by amlodipine and pranidipine treatment, whereas nicardipine−treatment significantly enhanced the overflow of NE.In preparations with active tone produced by methoxamine and guanethidine, the PNS−induced vasodilation mediated by calcitonin gene−related peptide(CGRP)−containing(CGRPergic)vasodilator nerves was not affected by these drugs.These results suggest that long−term treatment of SHR with long−acting drugs, amlodipine and pranidipine, reduces sympathetic adrenergic nerve function but calcium antagonists have no effect on CGRPergic nerve function.
- 社団法人 日本薬理学会の論文
- 2000-10-01
著者
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Gomita Yutaka
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Gomita Yutaka
岡山大学 医歯薬学総合研究科医薬管理学
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Gomita Y
Okayama Univ. Medical School Okayama Jpn
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ARAKI Hiroaki
Division of Pharmacy, Ehime University Hospital
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KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Gomita Y
Shujitsu Univ. School Of Pharmacy Okayama Jpn
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Araki H
Division Of Pharmacy Ehime University Hospital
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Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Gomita Yutaka
Department Of Hospital Pharmacy
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Gomita Yutaka
吉備国際大学 保健科学部作業療法学科
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Gomita Yutaka
科研製薬総合研究所
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Araki H
Dep. Of Clinical Pharmacology And Pharmacy Brain Sci. Ehime Univ. Graduate School Of Medicine Jpn
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FUTAGAMI Koujiro
Department of Hospital Pharmacy, Okayama University Medical School
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FUTAGAMI Kojiro
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University
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Gomita Y
Daiichi Coll. Pharmaceutical Sciences Fukuoka Jpn
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Kawasaki Hiromu
Dep. Of Clinical Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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NAKATSUMA Akira
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Ok
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KUROSAKI Yuji
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Ok
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Kawasaki Hiromu
岡山大学 医歯薬学総合研究科臨床薬学
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Kurosaki Yuji
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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Futagami Koujiro
Department Of Hospital Pharmacy Okayama University Medical School
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Futagami Kojiro
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kurosaki Yuji
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Sciences Graduate School Of
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Nakatsuma Akira
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
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