Effects of cholinergic drugs on aversive operant behavior induced by dorsal central gray stimulation in rats.
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概要
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Involvement of a central cholinergic mechanism in the central aversive operant behavior induced by dorsal central gray (DCG) stimulation was investigated in rats. Each animal was chronically implanted with bipolar electrodes at the DCG and was trained to press a lever to decrease the DCG-stimulation current. Physostigmine (0.1 and 0.2 mg/kg, i.p.) and arecholine (0.5-2.0 mg/kg, i.p.) produced an increase of DCG-stimulation threshold at 0.5-2 hr and 1-4 hr, respectively, after the administration. On the other hand, scopolamine (0.1-0.5 mg/ kg, i.p.) and atropine (5 and 10 mg/kg, i.p.) caused a marked decrease of the threshold at 0.5-2 hr after. In addition, an increasing effect of physostigmine on the threshold was decreased by scopolamine. Physostigmine potentiated the increasing effect of chlorimipramine on the stimulation threshold, while scopolamine suppressed it. These results suggest that the operant behavior induced by DCG-stimulation may be related to not only the central serotonergic mechanism but also to the cholinergic mechanism.
- 公益社団法人 日本薬理学会の論文
著者
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Gomita Yutaka
Department Of Hospital Pharmacy
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ICHIMARU YASUYUKI
Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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Fukuda Tamotsu
Department Of Pharmacy Ehime University School Of Medicine
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Moriyama Minehiro
Department Of Pharmacology Daiichi College Of Pharmaceutical Sciences:(present Address)department Of
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FUKUDA Tamotsu
Department of Hospital Pharmacy, Okayama University Medical School
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