Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate orally administered to rats.
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概要
- 論文の詳細を見る
The influence of emotional stress on the pharmacokinetics of isosorbide dinitrate (ISDN) was studied in rats. Plasma levels of orally administered ISDN and metabolites (5-isosorbide mononitrate and 2-isosorbide mononitrate) were lower in rats emotionally stressed by foot shock than in non-stressed control rats. The decrease in the ISDN levels may be mainly due to the delay of drug absorption from the gastrointestinal tract.
- 公益社団法人 日本薬理学会の論文
著者
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Gomita Yutaka
Department Of Hospital Pharmacy
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FURUNO KATSUSHI
Department of Hospital Pharmacy, Okayama University Medical School
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Furuno Katsushi
Department Of Hospital Pharmacy
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Araki Yasunori
Department Of Control Engineering Faculty Of Engineering Science Osaka University
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