EFFECTS OF CLOBAZAM ON AMYGDALOID AND HIPPOCAMPAL KINDLED SEIZURES IN RATS
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概要
- 論文の詳細を見る
The effect of clobazam, a 1,5-benzodiazepine, on kindling seizures was compared with the effects of 1,4-benzodiazepines, diazepam and bromazepam, in amygdaloid and hippocampal kindled rats. After kindled seizures were established (stage 5 seizure), the test drugs were administered intraperitoneally. In amygdaloid kindled rats, clobazam significantly suppressed the motor seizures (MS) at doses of 20 and 50 mg/kg and significantly shortened the duration of after-discharge (AD) at doses of 10 to 50 mg/kg. Diazepam at doses of 2 to 10 mg/kg and bromazepam at 1 to 5 mg/kg also significantly suppressed the MS and significantly shortened the duration of AD. Similar suppressive effects by these three benzodiazepines were observed in hippocampal kindled rats. From these results, clobazam was found to have a qualitatively similar but weaker anticonvulsive effect than those of 1,4-benzodiazepines.
- 公益社団法人日本薬学会の論文
著者
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Gomita Yutaka
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Gomita Y
Okayama Univ. Medical School Okayama Jpn
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Gomita Y
Shujitsu Univ. School Of Pharmacy Okayama Jpn
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Gomita Yutaka
Department Of Hospital Pharmacy
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Gomita Yutaka
吉備国際大学 保健科学部作業療法学科
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Gomita Y
Daiichi Coll. Pharmaceutical Sciences Fukuoka Jpn
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ICHIMARU YASUYUKI
Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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MORIYAMA MINEHIRO
Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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Ichimaru Yasuyuki
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Moriyama Minehiro
Department Of Pharmacology Daiichi College Of Pharmaceutical Sciences:(present Address)department Of
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