Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test : Involvement of the Expression of 5-HT_<2A> Receptor mRNA(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)_<2A> receptor function in the form of 5-HT_<2A> receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT_<2A> receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT_<2A> receptor mRNA levels may be involved in this phenomenon.
- 公益社団法人日本薬学会の論文
- 2008-02-01
著者
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Sendo Toshiaki
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Sendo Toshiaki
Department Of Hospital Pharmacy Okayama University Medical And Dental School
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Sagara Hidenori
Department Of Hospital Pharmacy Okayama University Medical School
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Sagara Hidenori
岡山大学 大学院医歯薬学総合研究科医薬管理学
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Sagara Hidenori
松山大学 医薬情報解析学
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Sagara Hidenori
岡山大学医学部附属病院 薬剤部
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Sagara Hidenori
岡山大学病院 薬剤部
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Sagara Hidenori
岡山大学 臨床薬剤学分野
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Gomita Yutaka
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Gomita Yutaka
岡山大学 医歯薬学総合研究科医薬管理学
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Gomita Y
Okayama Univ. Medical School Okayama Jpn
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KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Gomita Y
Shujitsu Univ. School Of Pharmacy Okayama Jpn
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Suemaru Katsuya
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Sendo T
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Sendo Toshiaki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Gomita Yutaka
Department Of Hospital Pharmacy
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Gomita Yutaka
吉備国際大学 保健科学部作業療法学科
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Gomita Yutaka
科研製薬総合研究所
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SHIBATA Kazuhiko
Department of Pharmaceutical Information Sciences, Matsuyama University
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KITAGAWA Kouhei
Department of Hospital Pharmacy, Okayama University Medical School
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FUJITANI Yoshika
Department of Hospital Pharmacy, Okayama University Medical School
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Gomita Y
Daiichi Coll. Pharmaceutical Sciences Fukuoka Jpn
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Kawasaki Hiromu
Dep. Of Clinical Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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MIYAZAKI Toshiaki
Department of Hospital Pharmacy Okayama University Medical School
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Shibata Kazuhiko
Department Of Hospital Pharmacy Okayama University Medical School
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Kawasaki Hiromu
岡山大学 医歯薬学総合研究科臨床薬学
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Fujitani Yoshika
Department Of Hospital Pharmacy Okayama University Medical School
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Kitagawa Kouhei
Department Of Pharmaceutical Care And Health Sciences Graduate School Of Medicine Dentistry And Phar
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kawasaki Yoichi
Department Of Pharmacy Okayama University Hospital
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Miyazaki Toshiaki
Department Of Biological Science And Technology Science University Of Tokyo
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Sendo Toshiaki
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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