Comparison of Short- and Long-Acting Benzodiazepine-Receptor Agonists With Different Receptor Selectivity on Motor Coordination and Muscle Relaxation Following Thiopental-Induced Anesthesia in Mice
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概要
- 論文の詳細を見る
In this study, we compared the effects of Type I benzodiazepine receptor–selective agonists (zolpidem, quazepam) and Type I/II non-selective agonists (zopiclone, triazolam, nitrazepam) with either an ultra-short action (zolpidem, zopiclone, triazolam) or long action (quazepam, nitrazepam) on motor coordination (rota-rod test) and muscle relaxation (traction test) following the recovery from thiopental-induced anesthesia (20 mg/kg) in ddY mice. Zolpidem (3 mg/kg), zopiclone (6 mg/kg), and triazolam (0.3 mg/kg) similarly caused an approximately 2-fold prolongation of the thiopental-induced anesthesia. Nitrazepam (1 mg/kg) and quazepam (3 mg/kg) showed a 6- or 10-fold prolongation of the anesthesia, respectively. Zolpidem and zopiclone had no effect on the rota-rod and traction test. Moreover, zolpidem did not affect motor coordination and caused no muscle relaxation following the recovery from the thiopental-induced anesthesia. However, zopiclone significantly impaired the motor coordination at the beginning of the recovery. Triazolam significantly impaired the motor coordination and muscle relaxant activity by itself, and these impairments were markedly exacerbated after the recovery from anesthesia. Nitrazepam and quazepam significantly impaired motor coordination, and the impairments were exacerbated after the recovery. These results suggest that the profile of recovery of motor coordination and muscle flaccidity after co-administration of benzodiazepine-receptor agonists and thiopental is related to the half-life and selectivity for the benzodiazepine-receptor subtypes.
- 社団法人 日本薬理学会の論文
- 2008-07-20
著者
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SUEMARU Katsuya
Division of Pharmacy, Ehime University Hospital
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ARAKI Hiroaki
Division of Pharmacy, Ehime University Hospital
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Araki Hiroaki
愛媛大学医学部附属病院 薬剤部
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Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Suemaru Katsuya
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Suemaru Katsuya
Ehime Univ. Graduate School Of Medicine Ehime Jpn
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Suemaru Katsuya
Division Of Pharmacy Ehime University Hospital
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Araki H
Dep. Of Clinical Pharmacology And Pharmacy Brain Sci. Ehime Univ. Graduate School Of Medicine Jpn
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Araki Hiroaki
Division Of Pharmacy Ehime University Hospital
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CUI Ranji
Department of Clinical Pharmacology and Pharmacy, Brain Science, Ehime University Graduate School of
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LI Bingjin
Department of Clinical Pharmacology and Pharmacy, Brain Science, Ehime University Graduate School of
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TANAKA Mamoru
Division of Pharmacy, Ehime University Hospital
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WATANABE Shinichi
Division of Pharmacy, Ehime University Hospital
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Shibata Kazuhiko
Department Of Hospital Pharmacy Okayama University Medical School
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Cui Ranji
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Li Bingjin
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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Tanaka Mamoru
Division Of Pharmacy Ehime University Hospital
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Tanaka Mamoru
Division Of Perinatology Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Araki Hiroaki
Division of Hospital Pharmacy, Ehime University Hospital
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