Long-Term Treatment With Angiotensin Converting Enzyme Inhibitor Restores Reduced Calcitonin Gene-Related Peptide-Containing Vasodilator Nerve Function in Mesenteric Artery of Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Effects of long-term treatment with angiotensin converting enzyme (ACE) inhibitor on decreased function of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRP nerves) in mesenteric resistance artery were investigated in spontaneously hypertensive rats (SHR). Eight-week-old SHR were treated for 7 weeks with 0.1% captopril, 0.01% temocapril, 0.05% pindolol or 0.005% hydralazine in drinking water. Long-term treatment with each drug significantly lowered mean blood pressure of SHR. In isolated and perfused mesenteric vascular beds with active tone, periarterial nerve stimulation (PNS) (0.5 to 8 Hz) produced frequency-dependent vasodilations, which were abolished by CGRP(8 - 37) (CGRP-receptor antagonist) and significantly smaller in SHR than in normotensive Wistar Kyoto rats. Treatment of SHR with captopril and temocapril but not with pindolol and hydralazine resulted in significantly greater PNS-induced vasodilation than in non-treated SHR, but ACE-inhibitor treatment did not affect vasodilation induced by exogenous CGRP. In captopril-treated SHR preparations, PNS evoked significantly larger CGRP-like immunoreactive release than in non-treated SHR. In non-treated 15-week-old SHR preparations, direct perfusion of captopril or temocapril (0.1 μM and 1 μM) did not modify frequency-dependent vasodilation in response to PNS. These results suggest that long-term ACE inhibitor treatment prevents or restores CGRP nerve function reduction in SHR.
- 社団法人 日本薬理学会の論文
- 1999-02-01
著者
-
Gomita Yutaka
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
-
Gomita Yutaka
岡山大学 医歯薬学総合研究科医薬管理学
-
Gomita Y
Okayama Univ. Medical School Okayama Jpn
-
ARAKI Hiroaki
Division of Pharmacy, Ehime University Hospital
-
KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
-
Gomita Y
Shujitsu Univ. School Of Pharmacy Okayama Jpn
-
Araki H
Division Of Pharmacy Ehime University Hospital
-
Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
-
Gomita Yutaka
Department Of Hospital Pharmacy
-
Gomita Yutaka
吉備国際大学 保健科学部作業療法学科
-
Gomita Yutaka
科研製薬総合研究所
-
Araki H
Dep. Of Clinical Pharmacology And Pharmacy Brain Sci. Ehime Univ. Graduate School Of Medicine Jpn
-
OKAZAKI Masatoshi
Department of Radiology, Fukuoka University School of Medicine
-
Gomita Y
Daiichi Coll. Pharmaceutical Sciences Fukuoka Jpn
-
Kawasaki Hiromu
Dep. Of Clinical Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
-
Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
-
NAKATSUMA Akira
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Ok
-
MIMAKI Yuichi
Department of Hospital Pharmacy, Okayama University School of Medicine
-
Okazaki Masatoshi
Department Of Hospital Pharmacy Okayama University School Of Medicine
-
Kawasaki Hiromu
岡山大学 医歯薬学総合研究科臨床薬学
-
Mimaki Yuichi
Department Of Hospital Pharmacy Okayama University School Of Medicine
-
Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
-
Nakatsuma Akira
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
関連論文
- Royal Jelly Ameliorates Insulin Resistance in Fructose-Drinking Rats(Pharmacognosy)
- The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats
- The Coadministration of Paroxetine and Low-Dose Aspirin Synergistically Enhances Gastric Ulcerogenic Risk in Rats(Pharmacology)
- Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method
- A New Approach for Evaluating Renal Function and Its Practical Application
- Preoperative extracranial carotid artery examination with ultrasonography in patients undergoing coronary artery bypass grafting in Japan
- Effects of Repeated Electroconvulsive Seizures on Spontaneous Alternation Behavior and Locomotor Activity in Rats(Pharmacology)
- Comparison of Short- and Long-Acting Benzodiazepine-Receptor Agonists With Different Receptor Selectivity on Motor Coordination and Muscle Relaxation Following Thiopental-Induced Anesthesia in Mice
- Effect of Aripiprazole on 5-HT_2 Receptor-mediated Wet-Dog Shake Responses and Disruption of Prepulse Inhibition in Rats
- Effect of Simultaneous Insertion of Oleaginous Base on the Absorption and on the Anticonvulsant Effect of Diazepam Suppository(Pharmacology)
- An Approach to Predict the Ductus-Arteriosus Dilating Effect Induced by Lipo-Prostaglandin E_1 in Newborn Rats Lacking Plasma Concentration-Time Data by the Pharmacological Response Kinetic Model
- Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats
- グリセロールおよびシスプラチンにより誘発された急性腎不全モデル病態における血中キニジン濃度推移の比較
- Effect of Methamphetamine and Imipramine on Cerebral Ischemia-Induced Hyperactivity in Mongolian Gerbils
- Capsaicin-Induced Increase of Intestinal Cefazolin Absorption in Rats
- ESTABLISHMENT OF NEUROTRANSMITTER-HYPERSENSITIVE PC12 VARIANT CELLS DEFICIENT IN NERVE GROWTH FACTOR-INDUCED NEURITE OUTGROWTH
- Immunosuppressant FK506 Induces Sustained Activation of MAP Kinase and Promotes Neurite Outgrowth in PC12 Mutant Cells Incapable of Differentiating
- Counseling of Patients with Bronchial Asthma, and Clinical Pharmacy Practice and Education of Pharmacy School Students
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Distribution of Adrenomedullin-Containing Perivascular Nerves and Its Alteration in Hypertension
- Development and Application of a Cocaine-Selective Electrode (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Neurotrophic Effect of Hepatic Growth Factor (HGF) on Reinnervation of Perivascular Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves Following Phenol-Induced Nerve Injury in the Rat Mesenteric Artery
- Effect of Diazepam on the Runway Method Using Priming Stimulation of Intracranial Self Stimulation Behavior
- The 5-HT_ Receptor Full Agonist, 8-OH-DPAT Inhibits ACTH-Induced 5-HT_ Receptor Hyperfunction in Rats : Involvement of 5-HT_ Receptors in the DOI-Induced Wet-Dog Shakes in ACTH-Treated Rats(Pharmacology)
- Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone-Treated Rats Are Not Affected by Chronic Imipramine Treatment : Possible Involvement of Enhanced 5-HT_-Receptor Expression in the Frontal Cortex
- Influence of Lactation on Plasma Phenobarbital Concentrations in Rats
- Pharmacokinetics of slow-release preparations of sodium valproate
- Simple and rapid analysis of lamotrigine, a novel antiepileptic, in human serum by high-performance liquid chromatography using a solid-phase extraction technique
- Pharmacokinetics of slow-release preparations of sodium valproate
- Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan
- Effects of Benzodiazepines on Low Rate Responding for Low Current Brain Stimulation Rewards
- Neuronal Nicoticic Receptor and Psychiatric Disorders: Functional and Behavioral Effects of Nicotine
- Combination of transileocolic vein obliteration and balloon-occluded retrograde transvenous obliteration is effective for ruptured duodenal varices
- Motivational Effect of Nomifensine in the Intracranial Self-Stimulation Behavior Using a Runway Method(Pharmacology)
- Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone-Treated Rats
- Motivational Effects of Methamphetamine as Measured by the Runway Method Using Priming Stimulation of Intracranial Self-stimulation Behavior(Analytical Biochemistry)
- Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test : Involvement of the Expression of 5-HT_ Receptor mRNA(Pharmacology)
- Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats
- Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve Function in the Mesenteric Artery of Spontaneously Hyupertensive Rats
- Long-Term Treatment With Angiotensin Converting Enzyme Inhibitor Restores Reduced Calcitonin Gene-Related Peptide-Containing Vasodilator Nerve Function in Mesenteric Artery of Spontaneously Hypertensive Rats
- CHANGES IN CIRCADIAN RHYTHM OF LOCOMOTOR ACTIVITY INDUCED BY CEREBRAL ISCHEMIA IN MONGOLIAN GERBILS
- EFFECTS OF CLOBAZAM ON AMYGDALOID AND HIPPOCAMPAL KINDLED SEIZURES IN RATS
- Effects of Chronic Administration of Sibutramine on Body Weight, Food Intake and Motor Activity in Neonatally Monosodium Glutamate-Treated Obese Female Rats: Relationship of Antiobesity Effect with Monoamines
- Effect of Dopaminergic Drugs on the Reserpine-Induced Lowering of Hippocampal Theta Wave Frequency in Rats
- Examination of Particulate Contamination after Opening Ampoules : Relationship between Ampoule Inner-diameter and Glass Particle Accumulation after Opening Ampoules
- Potentiation of _L-Dopa-Induced Behavioral Excitement by Histamine H_1-Receptor Antagonists in Mice
- Effect of TTC-909 on Cerebral Infarction Following Permanent Occlusion of the Middle Cerebral Artery in Stroke Prone Spontaneously Hypertensive Rats
- EFFECTS OF LIMBIC LESIONS, ESPECIALLY OF OLFACTORY BULBECTOMY ON SIMPLE CONDITIONED AVOIDANCE RESPONSE IN RATS
- Effect of Heat Exposure on Aminophylline-Induced Convulsions in Mice
- ENDOTHELIUM-INDEPENDENT VASORELAXATION INDUCED BY ACETYLCHOLINE
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Preface
- Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats
- Effect of nicotine and exposure to cigarette smoke on suppression of local graft-versus-host reaction induced by immunobilization stress in mice.
- Detecting Breast Cancer with Non-contrast MR Imaging: Combining Diffusion-weighted and STIR Imaging
- Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats
- Chronic Hyperinsulinemia Enhances Adrenergic Vasoconstriction and Decreases Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats
- Chronic Angiotensin II Inhibition Increases Levels of Calcitonin Gene-Related Peptide mRNA of the Dorsal ~Root Ganglia in Spontaneously Hypertensive Rats
- Age-Related Decrease in Calcitonin Gene-Related Peptide mRNA in the Dorsal Root Ganglia of Spontaneously Hypertensive Rats
- Endoscopic injection sclerotherapy with n-buty1-2-cyanoacrylate for ruptured duodenal varices
- Regulation of Vascular Function by Perivascular Calcitonin Gene-Related Peptide-Containing Nerves
- Preface
- Lafutidine Facilitates Calcitonin Gene-Related Peptide (CGRP) Nerve-Mediated Vasodilation via Vanilloid-1 Receptors in Rat Mesenteric Resistance Arteries
- Effect of Adrenomedullin on Adrenergic Vasoconstriction in Mesenteric Resistance Arteries of the Rat
- LIPO-MICRODIALYSIS : A NEW MICRODIALYSIS METHOD FOR STUDYING THE PHARMACOKINETICS OF LIPOPHILIC SUBSTANCES
- Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and-Independent Vasoconstriction in Rat Mesenteric Resistance Arteries
- Long-Term Inhibition of Angiotensin Prevents Reduction of Periarterial Innervation of Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves in Spontaneously Hypertensive Rats
- Decreased Depressor Response Mediated by Calcitonin Gene-Related Peptide(CGRP)-Containing Vasodilator Nerves to Spinal Cord Stimulation and Levels of CGRP mRNA of the Dorsal Root Ganglia in Spontaneously Hypertensive Rats
- Effect of TTC-909 on Cerebral Infarction Following Permanent Occlusion of the Middle Cerebral Artery in Stroke Prone Spontaneously Hypertensive Rats
- Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
- Characterization of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Resistance Arteries
- Nerve Growth Factor Suppresses Prostate Tumor Growth
- Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
- THE ROLE OF NORADRENERGIC AND SEROTONERGIC SYSTEMS IN THE HIPPOCAMPAL KINDLING EFFECT
- EFFECTS OF RESERPINE, α-METHYL-p-TYROSINE, P-CHLOROPHENYLALANINE AND 5, 7-DIHYDROXYTRYPTAMINE ON THE HIPPOCAMPAL KINDLING EFFECT IN RATS
- HIPPOCAMPAL KINDLING AND EFFECTS OF ANTIEPILEPTIC DRUGS
- EFFECTS OF BENZODIAZEPINES ON LOW RATE RESPONDING FOR LOW CURRENT BRAIN STIMULATION REWARDS
- THE EMOTIONAL COMMUNICATION BASED ON METHAMPHETAMINE MORTALITY AS THE INDEX IN OLFACTORY BULBECTOMIZED MICE
- INFLUENCE OF AGGREGATION ON THE ACTION OF METHAMPHETAMINE IN LOCOMOTOR ACTIVITY
- Nitrooxy Alkyl Apovincaminate Activates K^+ Currents in Rat Neocortical Neurons
- Differential Effects of Morphine on Operant Escape Behavior and Averse Symptom Induced by Dorsal Central Gray Stimulation in Rats
- New Molecular Mechanisms for Cardiovascular Disease : Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries
- Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
- Endothelium-Derived Relaxing Factor-Mediated Vasodilation in Mouse Mesenteric Vascular Beds
- Adrenergic Stimulation-Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries
- Anandamide Induces Endothelium-Dependent Vasoconstriction and CGRPergic Nerve-Mediated Vasodilatation in the Rat Mesenteric Vascular Bed
- Hyperinsulinemia induces hypertension associated with neurogenic vascular dysfunction resulting from abnormal perivascular innervations in rat mesenteric resistance arteries
- A New Method for Evaluation of Motivational Effects of Drugs
- Impairment of memory and changes in neurotransmitters induced by basal forebrain lesion in rats.
- Effects of cholinergic drugs on aversive operant behavior induced by dorsal central gray stimulation in rats.
- Behavioral effects of HR-592, a new derivative of indole.
- A Test–Retest Paradigm of the Forced Swimming Test in Female Mice Is not Valid for Predicting Antidepressant-Like Activity: Participation of Acetylcholine and Sigma-1 Receptors
- Changes in monoamine contents in the brains of Mongolian gerbils following a 5-min occlusion of the bilateral carotid arteries.
- Role of the amygdala in the hippocampal kindling effect of rats.
- Effect of minaprine on changes in monoamine contents in Mongolian gerbils with 5-min occlusion of common carotid arteries.
- Effect of minaprine and other reference drugs on passive avoidance impairment induced by cerebral ischemia in Mongolian gerbils.
- Auto-titration technique using intracranial self-stimulation and effects of antianxiety drugs.
- Neural systems activated by the aversive stimulation of dorsal central gray.
- Effects of methamphetamine on regional cerebral glucose utilization in rats with unilateral lesion of substantia nigra.
- Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate subcutaneously administered to rats.
- Effect of chronic administration of antidepressants on duration of immobility in rats forced to swim.
- Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate orally administered to rats.