Regulation of Vascular Function by Perivascular Calcitonin Gene-Related Peptide-Containing Nerves
スポンサーリンク
概要
- 論文の詳細を見る
The rat mesenteric artery is innervated by nonadrenergic noncholinergic (NANC) vasodilator nerves in which calcitonin gene-related peptide (CGRP), a potent vasodilator peptide, acts as a vasodilator transmitter. The inhibition of CGRPergic nerve function potentiates a vasoconstrictor response mediated by the sympathetic adrenergic nerve, suggesting that CGRPergic nerves inhibit adrenergic function and play a role in the regulation of mesenteric vascular tone. In contrast, norepinephrine released from adrenergic nerves presynaptically inhibits neurotransmission of CGRPergic nerves. Thus, both nerves reciprocally control the vascular tone. Pathophysiological studies have shown that an age-related decrease in CGRPergic nerve-mediated vasodilation, neurogenic CGRP release and CGRP mRNA levels in the dorsal root ganglia are found in spontaneously hypertensive rats (SHR), indicating a reduced function of CGRPergic nerves. Long-term treatment with angiotensin converting enzyme inhibitor and angiotensin II-receptor antagonist restores the reduced function of CGRPergic nerves, suggesting the involvement of angiotensin II in the malfunction of CGRPergic nerves in SHR.
- 社団法人 日本薬理学会の論文
- 2002-01-01
著者
-
KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
-
Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Natural Science And Technology Okay
-
Kawasaki H
Okayama Univ. Okayama Jpn
-
Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
関連論文
- Royal Jelly Ameliorates Insulin Resistance in Fructose-Drinking Rats(Pharmacognosy)
- Effect of Aripiprazole on 5-HT_2 Receptor-mediated Wet-Dog Shake Responses and Disruption of Prepulse Inhibition in Rats
- An Approach to Predict the Ductus-Arteriosus Dilating Effect Induced by Lipo-Prostaglandin E_1 in Newborn Rats Lacking Plasma Concentration-Time Data by the Pharmacological Response Kinetic Model
- Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats
- Effect of Methamphetamine and Imipramine on Cerebral Ischemia-Induced Hyperactivity in Mongolian Gerbils
- Counseling of Patients with Bronchial Asthma, and Clinical Pharmacy Practice and Education of Pharmacy School Students
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Distribution of Adrenomedullin-Containing Perivascular Nerves and Its Alteration in Hypertension
- Neurotrophic Effect of Hepatic Growth Factor (HGF) on Reinnervation of Perivascular Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves Following Phenol-Induced Nerve Injury in the Rat Mesenteric Artery
- Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone-Treated Rats Are Not Affected by Chronic Imipramine Treatment : Possible Involvement of Enhanced 5-HT_-Receptor Expression in the Frontal Cortex
- Influence of Lactation on Plasma Phenobarbital Concentrations in Rats
- Simple and rapid analysis of lamotrigine, a novel antiepileptic, in human serum by high-performance liquid chromatography using a solid-phase extraction technique
- Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone-Treated Rats
- Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test : Involvement of the Expression of 5-HT_ Receptor mRNA(Pharmacology)
- Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve Function in the Mesenteric Artery of Spontaneously Hyupertensive Rats
- Long-Term Treatment With Angiotensin Converting Enzyme Inhibitor Restores Reduced Calcitonin Gene-Related Peptide-Containing Vasodilator Nerve Function in Mesenteric Artery of Spontaneously Hypertensive Rats
- CHANGES IN CIRCADIAN RHYTHM OF LOCOMOTOR ACTIVITY INDUCED BY CEREBRAL ISCHEMIA IN MONGOLIAN GERBILS
- Effect of KW-4679, an Orally Active Anti-allergic Drug, on Antigen-Induced Airway Hyperresponsiveness in Actively Sensitized Guinea Pigs
- Effect of Heat Exposure on Aminophylline-Induced Convulsions in Mice
- ENDOTHELIUM-INDEPENDENT VASORELAXATION INDUCED BY ACETYLCHOLINE
- Malfunction of Vascular Control in Lifestyle-Related Diseases : Preface
- Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats
- Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats
- Chronic Hyperinsulinemia Enhances Adrenergic Vasoconstriction and Decreases Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats
- Age-Related Decrease in Calcitonin Gene-Related Peptide mRNA in the Dorsal Root Ganglia of Spontaneously Hypertensive Rats
- Regulation of Vascular Function by Perivascular Calcitonin Gene-Related Peptide-Containing Nerves
- Preface
- Lafutidine Facilitates Calcitonin Gene-Related Peptide (CGRP) Nerve-Mediated Vasodilation via Vanilloid-1 Receptors in Rat Mesenteric Resistance Arteries
- Effect of Adrenomedullin on Adrenergic Vasoconstriction in Mesenteric Resistance Arteries of the Rat
- LIPO-MICRODIALYSIS : A NEW MICRODIALYSIS METHOD FOR STUDYING THE PHARMACOKINETICS OF LIPOPHILIC SUBSTANCES
- Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and-Independent Vasoconstriction in Rat Mesenteric Resistance Arteries
- Long-Term Inhibition of Angiotensin Prevents Reduction of Periarterial Innervation of Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves in Spontaneously Hypertensive Rats
- Decreased Depressor Response Mediated by Calcitonin Gene-Related Peptide(CGRP)-Containing Vasodilator Nerves to Spinal Cord Stimulation and Levels of CGRP mRNA of the Dorsal Root Ganglia in Spontaneously Hypertensive Rats
- Effects of Natriuretic Peptides on the Centrally Mediated Pressor Response to Clonidine in Freely Moving Rats
- Characterization of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Resistance Arteries
- Nerve Growth Factor Suppresses Prostate Tumor Growth
- Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
- A Modified Fluorescence Polarization Immunoassay Method Incorporating Fat Emulsion (FE-FPIA) to Determine Cyclosporin A Concentrations in Rat Skin
- UPTAKE AND RELEASE OF 5-HYDROXYTRYPTAMINE IN ADRENERGIC NERVES OF THE RAT MESENTERIC ARTERY
- EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL ON THE CARDIOVASCULAR SYSTEM, AND PRESSOR AND BEHAVIORAL RESPONSES TO BRAIN STIMULATION IN RATS
- CARDIOVASCULAR CHANGES INDUCED BY LARGE DOSES OF CLONIDINE IN MICE
- Effect of Pharmacist Management on Serum Hemoglobin Levels with Renal Anemia in Hemodialysis Outpatients
- New Molecular Mechanisms for Cardiovascular Disease:Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries
- New Molecular Mechanisms for Cardiovascular Disease : Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries
- New Molecular Mechanisms for Cardiovascular Disease : Preface
- R-(−)-α-Methylhistamine, a Histamine H3 Receptor Agonist, Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries
- Endothelium-Derived Relaxing Factor-Mediated Vasodilation in Mouse Mesenteric Vascular Beds
- Adrenergic Stimulation-Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries
- Anandamide Induces Endothelium-Dependent Vasoconstriction and CGRPergic Nerve-Mediated Vasodilatation in the Rat Mesenteric Vascular Bed
- Involvement of Hypothalamic Periventricular GABAergic Nerves in the Central Pressor Response to Clonidine in Freely-Moving Conscious Rats
- Hyperinsulinemia induces hypertension associated with neurogenic vascular dysfunction resulting from abnormal perivascular innervations in rat mesenteric resistance arteries
- Neurogenic Vascular Responses in Male Mouse Mesenteric Vascular Beds
- The Mechanism of Calcitonin Gene-Related Peptide-Containing Nerve Innervation
- Neurogenic Vascular Responses in Male Mouse Mesenteric Vascular Beds
- Effects of methamphetamine on the twitch response in the rat isolated vas deferens.
- Pharmacological characterization of presynaptic .ALPHA.-adrenoceptors in the modulation of the 5-hydroxytryptamine release from vascular adrenergic nerves in the rat.
- Vascular Reactivity to Alpha Adrenoceptor Agonists in Freely Moving SHR and WKY
- Cardiovascular Responses Induced by Intracerebroventricular Injection of Angiotensin III in Freely Moving SHR
- Involvement of the increased calcium influx in positive inotropic action induced by N-ethylmaleimide in the bullfrog ventriculum.
- Intracerebroventricular Treatment with Vasopressin V1-Receptor Antagonist Inhibits Centrally-Mediated Pressor Response to Clonidine in Conscious Rats.
- Central .ALPHA.2-Adrenoceptor-Mediated Pressor Response to Clonidine in Conscious, Spontaneously Hypertensive Rats.
- Effect of neuropeptide Y on vasodilation mediated by Calcitonin Gene-Related Peptide(CGRP)-containing nerves in the mesenteric resistance vessel of the rat.