Effects of Natriuretic Peptides on the Centrally Mediated Pressor Response to Clonidine in Freely Moving Rats
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概要
- 論文の詳細を見る
Effects of intracerebroventricular (i.c.v.) treatment with atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) on the pressor response to i.c.v.-injected clonidine were investigated in conscious rats. I.c.v.-pretreatment with ANP (10 μg) or BNP (10 μg) inhibited the pressor response to i.c.v.-injected clonidine (10 μg). Systemic (i.v.) treatment with ANP and BNP had no such effect. These results suggest that natriuretic peptides in the brain modulate the centrally mediated pressor response to clonidine.
著者
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Takasaki Koichiro
Department Of Pharmacology Miyazaki Medical College
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Nakamura Shigeru
Department Of Applied Physics Tokyo Institute Of Technology:central Laboratory Hitachi Ltd.
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Nakamura Shigeru
Department of Pharmacology, Miyazaki Medical College
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