THE DIRECT CARDIODEPRESSANT ACTION OF METHAMPHETAMINE IN ISOLATED CARDIAC MUSCLE
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概要
- 論文の詳細を見る
Effects of d-methamphetamine and tyramine were studied on several physiological parameters in isolated rat heart muscle preparations. The sinoatrial rate and electrically-induced ventricular contractile force were suppressed dose-dependently by methamphetamine, although both the activities of cardiac muscle were effectively enhanced by tyramine. Clear-cut differences between the two amines were also demonstrated in their effect on ventricular excitability and functional refractoriness. Methamphetamine caused depressed excitability and increased refractoriness of cardiac muscle, whereas tyramine produced no change in its excitability, rather causing decreased refractoriness. It could be suggested from these results that methamphetamine is a direct cardiodepressant rather than a cardiac stimulant. In view of the structure-activity relationship, the direct cardiodepressant effect of methamphetamine was presumed to be basically related to so-called direct membrane effect.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Takasaki Koichiro
Department Of Pharmacology Miyazaki Medical College
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URABE MASANOBU
Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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URABE MASANOBU
Department of Pharmacology, Medical College of Miyazaki
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FUJITA SETSUHARU
Department of Pharmacology, Medical College of Miyazaki
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