Involvement of the increased calcium influx in positive inotropic action induced by N-ethylmaleimide in the bullfrog ventriculum.
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概要
- 論文の詳細を見る
In the electrically driven ventricular muscle (twitch response) of the bullfrog, N-ethylmaleimide (NEM, 10<SUP>-5</SUP> to 10<SUP>-3</SUP>M) caused a dose-dependent positive inotropic action (PIA). The NEM-induced PIA was reduced by pretreatment with verapamil (10<SUP>-5</SUP>M) and MnCl2 (10<SUP>-3</SUP>M) and was blocked by pre-treatment with 1-cysteine (2×10<SUP>-3</SUP>M). Ouabain (OU) produced a moderate PIA followed by a negative inotropic action (NIA) concomitant with a marked elevation of the resting tension. The OU-induced PIA at high concentrations (10<SUP>-5</SUP> and 10<SUP>-4</SUP>M) was significantly reduced only by verapamil. The PIA induced by either NEM or OU was hardly affected by propranolol. OU produced a greater inhibition of Na<SUP>+</SUP>-K<SUP>+</SUP> ATPase activity of cell membranes isolated from the ventricular muscle than that of NEM without affecting Mg<SUP>2+</SUP> dependent ATPase activity. Both NEM and isoprenaline but not OU restored the twitch response which disappeared in the potassium (20 mM K<SUP>+</SUP>)-depolarized muscle. The twitch response restored by NEM was abolished by the calcium antagonists, MnCl2 and verapamil and 1-cysteine but not by propranolol. The twitch response restored by isoprenaline was blocked by the calcium antagonists and propranolol but not by 1-cysteine. These results suggest that the NEM-induced PIA may result from the increased calcium influx into the muscle. The results also suggest that the mechanism of the NEM-induced PIA is discrete from that of the OU-induced PIA.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Yamamoto Ryuichi
Department Of Internal Medicine Japan Self Defense Forces Fukuoka Hospital
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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URABE Masanobu
Department of Pharmacology, Miyazaki Medical College
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Takasaki Koichiro
Department Of Pharmacology Miyazaki Medical College
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URABE MASANOBU
Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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KAWAI YUKIO
Department of Pharmacology, Miyazaki Medical College
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