THE MECHANISM OF THE REFLEX APNEA CAUSED BY NICOTINE.: INFLUENCES OF INTRAPERICARDIALLY INJECTED PROCAINE ON THE APNEA IN CATS, RABBITS AND DOGS
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概要
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It has been recognized that the apnea caused by intravenously in jected nicotine may be due to the pulmonary respiratory chemoreflex (Takasaki, 1956). The localization of the receptor responsible to the reflex, however, is not yet confirmed.On the other hand, it has been reported that the circulatory reflex originating in the receptor within the heart (Bezold-Jarisch effect defined by Dawes et al., 1954) is blocked by intrapericardial administration of procaine or the other local anesthetics (Kurotubo, 1942., Hukuda, 1951., Kido, 1953).The present experiment attempted to confirm that the receptor in the heart is not concerned in the nicotine apnea, using the intrapericardial in jection of procaine. In addition, the troubles occurred after intrapericardial administration of procaine were examined.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Nagasaki Nobuyuki
Department Of Pharmacology Kurume University School Of Medicine
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Takasaki Koichiro
Department Of Pharmacology Miyazaki Medical College
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MIYAZAKI NORIO
Department of Pharmacology, Kurume University School of Medicine
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SAKAI KUNIHIRO
Department of Pharmacology, Kurume University School of Medicine
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