Hypothermia and gastric lesions in rats exposed to immobilization stress.
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概要
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Male Wistar rats were exposed to immobilization stress and changes in rectal temperature and incidence of gastric lesions were examined. Rectal temperature in immobilized rats significantly decreased within 2 hours of immobilization and the significant decrease continued up to 24 hours of immobilization. Hypothermia induced by stress rapidly recovered to control levels when the rats were released from 18-hours of immobilization. Based on macroscopical occurrence of gastric lesions after exposure to immobilization stress for 12 hours, rats were divided into two groups, i. e., affected or non-affected rats by gastric lesions. When examined retrospectively, the former showed significantly lower rectal temperatures than the latter. Pretreatment with a synthesis inhibitor of serotonin (5-hydroxytryptamine, 5-HT), p-chlorophenylalanine (PCPA) at 250 mg/kg completely abolished the stress-induced hypothermia. This suggests that stressinduced hypothermia may be mediated by the brain's 5-HT system.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kohno Yasuko
Department Of Pharmacology Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim
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Noda Yasutaka
Institute Of Animal Experiment Kurume University School Of Medicine
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INANAGA Kazutoyo
Department of Nernropsychiatry and Institute of Brain Diseases, Kurume University School of Medicine
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Nagasaki Nobuyuki
Department Of Pharmacology Kurume University School Of Medicine
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Tanaka Masatoshi
Department Of Comprehensive Management Matsumoto University
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NISHIKAWA TADASHI
Department of Pharmacology, Kurume University School of Medicine
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