CHANGES OF IONIC CONCENTRATIONS IN SERUM AND BLOOD CELLS OF RATS AFTER LITHIUM ADMINISTRATION

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概要

• 論文の詳細を見る

• Lithium concentration in serum was higher than that in blood cells 3 hours after single lithium chloride administration (200 mg/kg ). The ratio of extra- to intracellular lithium concentration was, however, reversed 12 hours after single administration, indicating that excretion of intracellular lithium was much slower than that of extracellular one. Intracellular accumulation of lithium increased by repeated administrations of lithium, and concequently intracellular lithium concentration became nearly equal to extracellular one even 3 hours after a last administration. When blood cells accumulated lithium ions, the intracellular potassium decreased and the intracellular sodium also tended to decrease. It was suggested that therapeutic doses of lithium should be controled by measuring the intracellular lithium concentration, since the pharmacological or toxic actions of lithium would be directly associated with this concentration.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• Noda Yasutaka

  Institute Of Animal Experiment Kurume University School Of Medicine

• Koketsu Kyozo

  Department Of Physiology Kurume University School Of Medicine

• Nakamura Kenichi

  Laboratory of Pharmacotherapy, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Sciences, Josai University

• USHIJIMA ITSUKO

  Laboratory of Psychochemistry, Nakamura Psychiatric Hospital

• NAKAMURA KENICHI

  Laboratory of Psychochemistry, Nakamura Psychiatric Hospital

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