AN ANALYSIS OF 5-HT HYPERPOLARIZATION OF SYMPATHETIC GANGLION CELLS
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概要
- 論文の詳細を見る
Bullfrog sympathetic ganglion cells treated with nicotine are hyperpolarized with application of 5-HT. This 5-HT hyperpolarization, however, was not observed if preparations were pretreated with d-TC before being treated with nicotine. When preparations were treated with ACh or carbamylcholine, which transiently depolarizes ganglion cells, hyperpolarization did take place. Such was also observed in the presence of Ringers solution if preparations were pretreated with the K<SUP>+</SUP>-free Ringers solution. These results suggested that ganglion cells were hyperpolarized by the action of 5-HT when the Na<SUP>+</SUP>-pump of these cells was accelerated by accumulation of intracellular Na<SUP>+</SUP>, as the result of a transient depolarization or extracellular K<SUP>+</SUP> deficiency.
- 社団法人 日本薬理学会の論文
著者
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Koketsu Kyozo
Department Of Physiology Kurume University School Of Medicine
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SHIRASAWA Yoshiaki
Tokyo Research Laboratory, Kowa Co., Ltd.
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KOKETSU Kyozo
Department of Physiology, Kuruine University School of Medicine
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SHIRASAWA Yoshiaki
Tokyo Research Laboratories, Kowa Co., Ltd.
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