Action Potentials of Bullfrogs Ventricular Muscles in the Sodium-Free Hydrazine Solution

概要

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Bullfrogs ventricular muscle fibers were able to generate the action potentials in the sodium-free hydrazine solution. The shape of these action potentials was quite different from that of the action potentials recorded in the Ringers solution. In the sodium-free hydrazine solution, the absolute value of the resting membrane potential was smaller and the action potentials showed a slower maximum rate of rise, a markedly enhanced overshoot and a shorter duration of the plateau phase. Tetrodotoxin (TTX) or procaine added to the sodium-free hydrazine solution decreased the maximum rate of rise of the action potentials, whereas manganese suppressed the overshoot and the plateau phase without affecting the maximum rate of rise. These results indicated that the ionic mechanism underlying the production of the action potentials of bullfrogs heart muscles in the sodium-free hydrazine solution is essentially identical to that in the Ringers solution. In other words, hydrazinium ion is able to perfectly substitute for sodium ion during the generation of the action potentials.
International Heart Journal刊行会の論文