Effect of Hydrazine on Bullfrog Heart Muscles in the Excess Potassium Solution
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概要
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Electrical and mechanical response of bullfrogs heart muscle affected by hydrazine was investigated in the high K+ solution. Hydrazine as well as adrenaline in the excess K+ solution enhances the overshoot, whereas ouabain suppresses the overshoot. The increased contraction by hydrazine under the influence of excess K+ ions is more persistent than that by adrenaline. A complete loss of excitability of membrane due to excess K+ ions is also recovered by hydrazine as well as adrenaline.In conclusion, the mode of a positive inotropic action of hydrazine would be essentially similar to that of adrenaline. Presumably, hydrazine increases the permeability of membrane to calcium ions.
- International Heart Journal刊行会の論文
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