Effects of a TRH analog (DN-1417) on hippocampal pyramidal neurons in vitro.

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概要

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• The effect of DN-1417 (γ-butyrolactone-γ-carbonylhistidyl-prolinamide citrate), a TRH analog, on the electrical activities of hippocampal pyramidal neurons in the guinea-pig brain slice was studied with intracellular recording methods. DN-1417 caused a 2-5 mV hyperpolarization in approximately 25% of the neurons examined. The behavior of the DN-induced hyperpolarization in different ionic media suggested that it was produced by an increased potassium conductance. DN-1417 decreased the spontaneous firing of the pyramidal neurons by inhibiting the fast and slow prepotentials. The excitatory postsynaptic potentials (EPSPs) were also reduced by DN-1417, and this reduction appeared to be presynaptic in origin. The inhibitory nature of the DN -1417 actions on the hippocampal pyramidal neurons is compatible with its antiepileptic action recently reported (Inanaga et al. 1981).

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• Inokuchi Hiroe

  Department Of Physiology Kurume University School Of Medicine

• Nakamura Jun

  Department Of Environmental Sciences And Engineering University Of North Carolina

• INANAGA Kazutoyo

  Department of Nernropsychiatry and Institute of Brain Diseases, Kurume University School of Medicine

• NISHI SYOGORO

  Department of Physiology Kurume University School of Medicine

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