Muscarinic M2 receptors on cardiac ganglion neurons of the guinea-pig Heart.
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概要
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Intracellular recordings were made from neurons of the cardiac ganglion of the guinea-pig heart. Application of muscarinic agonists produced a depolarization in the majority of neurons. The change in membrane conductance underlying the depolarization consisted of an initial low-conductance phase followed by a high-conductance phase. The first component was probably due to suppression of a potassium conductance, and the second was likely generated by activation of a chloride conductance. Both components of the depolarization were blocked by pirenzepine with an antagonist dissociation constants (K<SUB>D</SUB>) of 200-900 nM, suggesting that both are mediated through a muscarinic M<SUB>2</SUB> receptor.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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MIHARA Satoshi
Department of Physiology, Kurume University School of Medicine
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Mihara Satoshi
Department Of Neurosurgery Kurume University School Of Medicine
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Ikeda Kozo
Department of Chemistry Faculty of Science Kyushu University
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NISHI SYOGORO
Department of Physiology Kurume University School of Medicine
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