The Effect of a TRH Analog on Pyramidal Neurons in the Guinea-pig Hippocampus in vitro
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概要
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A TRH analog (DN-1417; γ- butyrolactone -γ- carbonyl - histidylproliamide citrate) with antiepileptic actions altered the electrical activities of hippocampal pyramidal neurons in the guinea-pig brain slice as measured with intracellular recording techniques. DN-1417 hyperpolarized about 20% of the neurons examined. This hyperpolarization was accompanied by an increase in a voltage-dependent potassium conductance. DN-1417 suppressed spontaneous action potentials by depressing spontaneous oscillations of the membrane potential. The oscillations were reduced by DN-1417 through a blockade of tetrodotoxin sensitive non-inactivating Na channels. DN-1417 decreased the amplitudes of EPSPs by a presynaptic depressant action.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Inokuchi Hiroe
Department Of Physiology Kurume University School Of Medicine
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Nakamura Jun
Department Of Environmental Sciences And Engineering University Of North Carolina
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INANAGA Kazutoyo
Department of Nernropsychiatry and Institute of Brain Diseases, Kurume University School of Medicine
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NISHI SYOGORO
Department of Physiology Kurume University School of Medicine
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INOKUCHI HIROE
Departments of physiology, Kurume University School of Medicine
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