A Thyrotropin Releasing Hormone Analog, DN -1417, Increases Endogenous Dopamine Release from Slices of Rat Striatum and Nucleus Accumbens
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概要
- 論文の詳細を見る
Endogenous dopamine (DA) released from slices of rat striatum and n. accumbens into the superfusate was quantified with high performance liquid chromatography (HPLC) combined with an electrohemical detector (ECD). The basal efflux of DA from slices of rat striatum and n. accumbens were 600 pg/mg protein/10 min and 400 pg/mg protein/10 min, respectively. Compared with normal K<SUP>+</SUP> Krebs-Ringer solution, 25 mM K<SUP>+</SUP> Krebs-Ringer solution significantly incleased (about 20 times) the DA efflux. This stimulant effect of high K<SUP>+</SUP> did not occur in Ca<SUP>2+</SUP> deficient Krebs - Ringer solution. Methamphetamine (10<SUP>-7</SUP> -10<SUP>-3</SUP>M) caused significant increases in DA efflux in a dose dependent manner. This system may be quite useful to investigate endogenous DA releasing mechanisms in slices of rat brain. Thyrotropin releasing hormone (10<SUP>-5</SUP> -10<SUP>-3</SUP>M) did not increase the DA release from either the n. accumbens or the striatum. On the other hand, DN -1417, γ-butyrolactone-γ-histidyl-prolinamide citrate, caused a significant increase in DA efflux from both regions. Removal of Ca<SUP>2+</SUP> from the Krebs-Ringer solution abolished the effect of DN-1417. The stimulant effect of DN -1417 seemed to be greater in the n. accumbens than in the striatum.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Yamada Shigeto
Institute Of Brain Diseases Kurume University School Of Medicine
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KOJIMA HIDEKI
Institute of Brain Diseases, Kurume University School of Medicine
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Nakamura Jun
Department Of Environmental Sciences And Engineering University Of North Carolina
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Kojima Hideki
Institute Of Brain Diseases Kurume University School Of Medicine
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Anraku Shigemi
Institute Of Brain Diseases Kurume University School Of Medicine
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INANAGA Kazutoyo
Department of Nernropsychiatry and Institute of Brain Diseases, Kurume University School of Medicine
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TSUTSUMI TETSUYUKI
Institute of Brain Diseases Kurume University School of Medicine
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NISHI SYOGORO
Institute of Brain Diseases Kurume University School of Medicine
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