The effects of exogenous GM1 ganglioside on neurotoxin induced damage of cerebral serotonin nerve terminals in adult rats.

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概要

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• The effects of exogenous GM1 ganglioside (GM1) on neurotoxininduced damage of cerebral serotonin (5-HT) nerve terminals in adult rats were studied with neurochemical and immunocytochemical techniques. 2 mM 5, 7-dihydroxytryptamine (5, 7-HT) was infused, intracortically, via an osmotic minipump for 7 days. Significant decreases in 5-HT and 5-hydroxy-indole 3-acetic acid (5-HIAA) levels and in the number of 5-HT nerve terminals were found in restricted areas around the infusion points. Treatment with GM1 (20 mg/kg, i. p., daily) for 3 days before the 5, 7-HT infusion and for another 7-14 days after 5, 7 -HT infusion significantly enhanced 5-HT recovery, 5-HIAA recovery, the number of the nerve terminals at the infusion points, and 5-HIAA recovery in areas caudal to the infusion points. GM1 had no inhibitory effects on the 5, 7-HT-induced 5-HT depletion acutely, indicating that GM1 does not suppress the direct neurotoxic actions of 5, 7-HT. These results indicate that the effect of GM1 may be related to a stimulatory effect on regrowth and/or to a protective action against degeneration of 5-HT axons following the initial 5, 7-HT induced lesion of the 5-HT nerve terminals.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• Nagatsu Ikuko

  Department Of Anatomy And Physiology Aichi Prefectural College Of Nursing

• Yamada Shigeto

  Institute Of Brain Diseases Kurume University School Of Medicine

• Yokoo Hideyasu

  Institute Of Brain Diseases Kurume University School Of Medicine

• Inanaga Kazutoyo

  Chikusuikai Hospital

• TSUTSUMI TETSUYUKI

  Institute of Brain Diseases Kurume University School of Medicine

• NISHI SYOGORO

  Institute of Brain Diseases Kurume University School of Medicine

• NAGATSU IKUKO

  Department of Anatomy, School of Medicine, Fujita-gakuen Health University

• KOJIMA HIDEKI

  Chikusuikai Institute for Neuroinformation

• JONSSON GÖSTA

  Department of Histology, Karolinska Institutet

• TOFFANO GINO

  Fidia Research Laboratories, Department of Cytophamacology

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