Effects of Benzamide Derivatives on Dopamine Release from Striatal Slices of Rats.

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概要

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• The effects of the benzamide derivatives, (-)-sulpiride, sultopride and nemonapride, on spontaneous and electrically evoked dopamine (DA) release from striatal slices of rats were investigated. Nemonapride at concentrations of 100 nM or higher caused a dose-dependent increase in spontaneous DA release from the slices. (-)-Sulpiride and sultopride had little effect on spontaneous DA release. The electrically evoked DA release was enhanced by (-)-sulpiride at concentrations of 100 nM or higher in the superfusate and reduced by nemonapride at 100 nM or higher. Sultopride caused a small increase in the evoked release of DA. The different activities of these drugs on DA release may account for the different clinical results they produce.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• Yamada Shigeto

  Institute Of Brain Diseases Kurume University School Of Medicine

• NISHI SYOGORO

  Institute of Brain Diseases Kurume University School of Medicine

• YOKOO HIDEYASU

  Department of Neuropsychiatry, Kurume University School of Medicine

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