Effects of Angiotensin II on Regional Brain Noradrenaline Metabolism in Non-Stressed and Stressed Rats.
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概要
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By measuring levels of noradrenaline (NA) and its major metabolite, 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO<SUB>4</SUB>), in various rat brain regions, the effects of angiotensin II (AT II) injected intracerebroventricularly (ICV) were investigated in non-stressed and stressed rats. Immobilization stress with a wire mesh was employed. Immobilization stress induced significant increases in MHPG-SO<SUB>4</SUB> levels in all brain regions examined, i, e., hypothalamus, amygdala, thalamus, midbrain, hippocampus, cerebral cortex and locus coeruleus (LC) region, which suggests that stress increases NA release in these regions. AT II (1 and 10 μg), injected ICV 5 min before exposure to stress for 60 min, attenuated stress-induced increases in MHPG-SO<SUB>4</SUB> levels in the hypothalamus, thalamus and amygdala. AT II, injected ICV in non-stressed rats at 65 min before sacrifice, significantly elevated MHPG-SO<SUB>4</SUB> levels in the midbrain, cerebral cortex, thalamus and LC region. These results indicate that the attenuating effect of AT II on stress-induced increases in brain NA release are, in part, related to the reduction of fear and/or anxiety of the animals exposed to stress.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Yoshida Masami
Department of Cardiology, Himeji Cardiovascular Center
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Tsuda Akira
Department Of Clinical And Laboratory Medicine Akita University School Of Medicine
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Tanaka Masatoshi
Department Of Comprehensive Management Matsumoto University
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TAKEDA SHIGEKO
Department of Pharmacology, Kurume University School of Medicine
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KOGA CHIHIRO
Department of Pharmacology, Kurume University School of Medicine
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KOGA CHIHIRO
Department of Oral Surgery
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YOKOO HIDEYASU
Department of Neuropsychiatry, Kurume University School of Medicine
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GEORGIEVI VASIL
Department of Pharmacology, Kurume University School of Medicine
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