Effect of haloperidol administration on serum MHPG-SO4 levels in chronic schizophrenics.
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概要
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Eight chronic schizophrenic patients, free from neuroleptics for more than one month, and seven normal adults were administered a daily dose of haloperidol, 3mg, orally for one week. The major metabolite of noradrenaline (NA), 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO<SUB>4</SUB>), was measured fluorometrically in sera before and after the drug administration to examine brain NA metabolism. Serum MHPG-SO<SUB>4</SUB> levles in chronic schizophrenics were significantly lower than normal adults before drug ingestion. Although single administration of haloperidol failed to affect MHPG-SO<SUB>4</SUB> levels in both groups, repeated administrations of the drug for one week significantly decreased the metabolite levels in both groups. However, no difference was observed between two groups in the percent decrease of MHPG-SO<SUB>4</SUB> levels after repeated administrations of the drug. These data suggest that brain NA metabolism may be different in chronic schizophrenics compared to that in normal adults.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kohno Yasuko
Department Of Pharmacology Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim
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Ida Yoshishige
Department Of Pharmacology Kurume University School Of Medicine
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Hoaki Yoshio
Department Of Pharmacology Kurume University School Of Medicine
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Tanaka Masatoshi
Department Of Comprehensive Management Matsumoto University
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NISHIKAWA TADASHI
Department of Pharmacology, Kurume University School of Medicine
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