Time-Related Effects of Apomorphine on Noradrenaline Metabolism and Their Regional Differences in Rat Brain
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概要
- 論文の詳細を見る
In the whole brain of rats, apomorphine in doses of 5-10 mg/kg elevated noradrenaline (NA) level 10-20 min after s.c. injection, but reduced NA level 60-90 min after injection in doses of 2-10 mg/kg associated with increased level of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO<SUB>4</SUB>). With 5 mg/kg of apomorphine, NA content in the pons+medulla oblongata and midbrain showed biphasic changes as seen in the whole brain, whereas NA content increased in the cerebral cortex and hippocampus after 10-20 min, and decreased in the hypothalamus and amygdala after 60 min. Apomorphine in 0.1-0.2 mg/kg did not cause marked changes in brain NA metabolism. These results show that high doses of apomorphine which stimulate postsynaptic dopamine receptors have variable effects on noradrenergic neurons depending upon the time after injection and the brain region under investigation.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kohno Yasuko
Department Of Pharmacology Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim
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Ida Yoshishige
Department Of Pharmacology Kurume University School Of Medicine
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Hoaki Yoshio
Department Of Pharmacology Kurume University School Of Medicine
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Nagasaki Nobuyuki
Department Of Pharmacology Kurume University School Of Medicine
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Tanaka Masatoshi
Department Of Comprehensive Management Matsumoto University
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NAKAGAWA RYOICHI
Department of Pharmacology, Kurume University School of Medicine
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TAKEDA SHIGEKO
Department of Pharmacology, Kurume University School of Medicine
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NAKAGAWA RYOICHI
Department of Pharmacology Kurume University Shcool of Medicine
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IIMORI KENICHIRO
Department of Pharmacology, Kurume University School of Medicine
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