Glucocorticoid attenuates increases in rat brain noradrenaline turnover induced by intense stress.
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概要
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The effects of altered pituitary-adrenocortical function on contents of noradrenaline (NA) and its principal metabolite, 3-methoxy-4-hydroxy-phenylethyleneglycol sulfate (MHPG-SO<SUB>4</SUB>) in brain regions of the rat exposed to acute intense stress (electric tail shock under conditions of immobilization) were investigated. Bilateral adrenalectomy significantly potentiated the stress-induced decreases in NA contents in the hypothalamus and thalamus, and the increases in MHPG-SO<SUB>4</SUB> levels in the hypothalamus, amygdala, and thalamus. Supplementary administration of corticosterone attenuated both of these decreases of the amine and the increases of the metabolite. The results suggest that glucocorticoid secreted via the pituitary-adrenocortical axis has an inhibitory effect in part on the increased turnover of NA in some brain regions induced by acute intense stress.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kohno Yasuko
Department Of Pharmacology Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim
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Ida Yoshishige
Department Of Pharmacology Kurume University School Of Medicine
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Nagasaki Nobuyuki
Department Of Pharmacology Kurume University School Of Medicine
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Tanaka Masatoshi
Department Of Comprehensive Management Matsumoto University
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NAKAGAWA RYOICHI
Department of Pharmacology Kurume University Shcool of Medicine
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IIMORI KENICHIRO
Department of Pharmacology, Kurume University School of Medicine
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