Phase I Study on Mianserin Hydrochloride (Org GB 94):Safety and Tolerance
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概要
- 論文の詳細を見る
Safety and tolerance studies on a newly introduced antidepressant, Org GB 94 were performed on 6 healthy male volunteers ranging in age from 23 to 40 years old. Org GB 94 was administered orally in the dose range of 10-40 mg/day. After the drug administration, there were no unusual findings with the physical and hematological examinations, liver function tests, serum-electrolytes, urea nitrogen, pancreatic function tests, urinalysis, ECG and EEG, except for a tendency for a slight decrease in blood pressure and a slight tachycardia after medication<BR>From these results, the safety and tolerance in the dose range of 10-40 mg Org GB 94/day were so confirmed that we feel we have obtained enough background data to proceed with the Phase II study.
- 一般社団法人 日本臨床薬理学会の論文
著者
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Ogawa Nobuya
Department Of Clinical Pharmacology Ehime University School Of Medicine
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INANAGA Kazutoyo
Department of Nernropsychiatry and Institute of Brain Diseases, Kurume University School of Medicine
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Tanaka Masatoshi
Department Of Comprehensive Management Matsumoto University
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TANAKA Masatoshi
Department of Pharmacology and Institute of Brain Diseases, Kurume University School of Medicine
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HASUZAWA Hiroaki
Department of Neuropsychiatry, Kurume University School of Medicine
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