Effects of a TRH Analog (DN-1417) and TRH-T on the Electroconvulsive Threshold
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概要
- 論文の詳細を見る
Cannulas were chronically implanted in the ventriculus lateralis of rats. The anticonvulsant effects of DN-1417 (γ-butyrolactone-γ-carbonyl-histidyl-prolinamide citrate) and TRH-T (pyroglutamyl-histidyl-prolinamide tartrate) were analyzed by observing the changes in convulsive threshold to electrical stimulation. Both DN-1417 and TRH-T had no significant effect on the electroconvulsive threshold. DN-1417 had an anticonvulsant effcet in animals pretreated with α-methylparatyrosine (α-MT). When rats were pretreated with FLA-63, a dopamine-β-hydroxylase inhibitor, the convulsive threshold was only slightly different from the control threshold, therefore, the decrease in the convulsive threshold by α-MT must be due primarily to a decrease in dopamine (DA) content. Changes in the DA content of the striatum also suggested that the anticonvulsant effect of DN-1417 was due to its DA releasing action. Furthermore, the anticonvulsant effect of DN-1417 seemed to have no relationship to the inhibitory activity of GABA.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Ishibashi Kenji
Department Of Applied Quantum Physics And Nuclear Engineering Faculty Of Engineering Kyushu Universi
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Yamada Shigeto
Institute Of Brain Diseases Kurume University School Of Medicine
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Nakamura Jun
Department Of Environmental Sciences And Engineering University Of North Carolina
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INANAGA Kazutoyo
Department of Nernropsychiatry and Institute of Brain Diseases, Kurume University School of Medicine
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Uchimura Naohisa
Department Of Neuropsychiatry Kurume University
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KOJIMA HIDEKI
Institute of Brain Diseases
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TSUTSUMI TETSUYUKI
Department of Neuropsychiatry, Kurume University School of Medicine
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