Compensatory Renal Growth in Uninephrectomized Immature Rats: Proliferative Activity and Epidermal Growth Factor
スポンサーリンク
概要
- 論文の詳細を見る
Compensatory response to uninephrectomy in immature animals is stronger compared with that in adult ones and the response is due mainly to renal cell proliferation. The present study explored to show the growth pattern of the remaining kidney immediately after uninephrectomy in immature rats with special reference to proliferating activity and epidermal growth factor (EGF). Immunolocalizations of proliferating cell nuclear antigen (PCNA) and EGF in immature rat kidney were examined during the first three days after uninephrectomy. Semi-quantitative analysis of the expression of preproEGF mRNA was performed. One day after the operation, the PCNA positive cell ratios in the glomeruli and the proximal tubules were significantly higher in unilaterally nephrectomized (UNx) rats than in sham-operated (Sham) rats. In UNx and Sham rats, the proximal and distal tubular cells showed positive reactions to EGF antibody. The positive reaction of proximal tubules to EGF antibody was weaker in UNx than in Sham rats 1 day after the operation, while the degree of reactivity was not different between UNx and Sham rats 3 days after the operation. The level of expression of preproEGF mRNA in the kidney was significantly lower in UNx than in Sham rats 1 day after the operation. These results indicate that unilateral nephrectomy in immature rats causes increased proliferative activity and decreased expression of EGF in the remaining kidney during the early period of compensatory renal growth.
- 社団法人 日本獣医学会の論文
著者
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MINO Masaki
Department of Neurosurgery, Aomori Prefectural Central Hospital
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Kondo Tomohiro
Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of
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OKADA Toshiya
Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of
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TAKESHITA Ai
Department of Integrated Structural Bioscience, Division of Veterinary Science, Graduate School of L
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KUSAKABE Ken
Department of Integrated Structural Bioscience, Division of Veterinary Science, Graduate School of L
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KATO Keiko
Department of Laboratory Animal Science, Division of Veterinary Science, Graduate School of Life and
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NAKAMURA Jun
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill
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Mino Masaki
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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Kusakabe Ken
Department Of Anatomy And Biology Osaka Medical College
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Takeshita Ai
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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Okada T
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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岡田 利也
大阪府立大学
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Okada Toshiya
Department Of Veterinary Anatomy College Of Agriculture Osaka Prefecture University
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Kondo Tomohiro
Department Of Chemical Engineering Graduate School Of Engineering Tohoku University
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Okada T
Department Of Laboratory Animal Science Division Of Veterinary Science Graduate School Of Life And E
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Okada Toshiya
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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Nakamura Jun
Department Of Environmental Sciences And Engineering University Of North Carolina
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MUKAMOTO Masafumi
Department of Infectious Disease Control, Division of Veterinary Science, Graduate School of Life an
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OMOTO-KITAO Mika
Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of
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Kato Keiko
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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Kato Keiko
Department Of Dermatology Kurume University School Of Medicine
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Kato Keiko
Department Of Animal Medical Sciences Kyoto Sangyo University
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Kondo Tomohiro
Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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OKADA Toshiya
Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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MINO Masaki
Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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MUKAMOTO Masafumi
Department of Infectious Diseases Control, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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