子宮NK細胞はマウス妊娠子宮においてEGFを産生する
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概要
- 論文の詳細を見る
Uterine natural killer (uNK) cells belong to the large granular lymphocytes in the murine pregnant uterus and play essential roles in pregnancy success. We defined whether uNK cells can produce epidermal growth factor (EGF) important for implantation and embryo growth. The uNK cells were immunohistochemically positive for anti-EGF antibody especially during days 6 to 9 and at day 15 of pregnancy. Immunoreaction for EGF receptor was observed on the stromal cells in the metrial gland and trophoblasts in the placental labyrinth. EGF secretion (72.1 ± 2.25 ng/10^4 cells) was noted in cultured uNK cells isolated from the metrial gland at day 15 of pregnancy. Treatment of anti-asialo-GM1 antibody raised the level of EGF (129 ± 21.5 ng/10^4 cells). These results suggest uNK cell can produce and release EGF for placental development.
- 社団法人日本獣医学会の論文
- 1999-08-25
著者
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OKADA Toshiya
Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of
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KUSAKABE Ken
Department of Integrated Structural Bioscience, Division of Veterinary Science, Graduate School of L
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KISO Yasuo
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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Sasaki Fumihiko
Department of Internal Medicine, Fukui Cardiovascular Center
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Kiso Yasuo
Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer
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Kiso Yasuo
Department Of Veterinary Anatomy Faculty Of Agriculture Yamaguchi University
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Mino Masaki
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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Kusakabe K
Department Of Laboratory Animal Science Division Of Veterinary Science Graduate School Of Life And E
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Kusakabe Ken
Department Of Anatomy And Biology Osaka Medical College
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Okada T
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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岡田 利也
大阪府立大学
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Okada Toshiya
Department Of Veterinary Anatomy College Of Agriculture Osaka Prefecture University
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Sasaki F
Department Of Veterinary Anatomy Graduate School Of Agriculture And Biological Sciences Osaka Prefec
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Okada T
Department Of Laboratory Animal Science Division Of Veterinary Science Graduate School Of Life And E
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Okada Toshiya
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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OHMOTO Mika
Departments of Veterinary Anatomy, College of Agriculture, Osaka Prefecture University
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MUKAMOTO Masafumi
Veterinary Immunology, College of Agriculture, Osaka Prefecture University
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Ohmoto Mika
Departments Of Veterinary Anatomy College Of Agriculture Osaka Prefecture University
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Kiso Y
Yamaguchi Univ. Yamaguchi Jpn
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Sasaki F
Departments Of Veterinary Anatomy College Of Agriculture Osaka Prefecture University
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Sasaki Fumihiko
Department Of Internal Medicine Fukui Cardiovascular Center
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岡田 利也
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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Kokubu Keiji
The United Graduate School Of Veterinary Science Yamaguchi University
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Masafumi Mukamoto
Department Of Integrated Structural Biosciences Division Of Veterinary Science Graduate School Of Life And Environmental Sciences Osaka Prefecture University
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Kiso Yasuo
Laboratory Of Basic Veterinary Science The United Graduate School Of Veterinary Science Yamaguchi University
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日下部 健
Departments of Veterinary Anatomy, College of Agriculture, Osaka Prefecture University
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大元 美佳
Departments of Veterinary Anatomy, College of Agriculture, Osaka Prefecture University
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