IGF-I過剰発現はマウス胎盤形成期に流産を引き起こす
スポンサーリンク
概要
- 論文の詳細を見る
To understand the role of IGF-I in murine pregnancy, we studied the reproductive performance of IGF-I overexpressed mice. Fetal loss occurred only in the transfected uterine horn during Day 10-15 of pregnancy. The placenta appeared healthy until Day 10 of pregnancy. From Day 12, the decidua basalis of the transfected horn increased in thickness. The vascular lumen was expanded, and most of embryos were dead. Uterine Natural Killer cells did not undergo apoptosis from Day 10 to Day 15 when they usually go through apoptosis. Thus, it is likely that IGF-I plays a role in the decidual formation through regulation of uNK cells. This is the first report to demonstrate that IGF-I overexpression can cause fetal loss during murine placentation.
- 日本繁殖生物学会の論文
著者
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HONDO Eiichi
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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KISO Yasuo
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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中村 織江
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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本道 栄一
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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難波 泰治
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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NAMBA Yasuharu
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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NAKAMURA Orie
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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