Spontaneous Endometrial Hyperplasia in the Uteri of IL-2 Receptor Beta-Chain Transgenic Mice
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概要
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We found frequent and spontaneous proliferation of glandular epithelium and dilated cysts in the uteri of interleukin-2 receptor (IL2R) β-chain transgenic (Tg2Rβ) mice. The aim of this study was to examine the involvement of IL2R β-chain in the pathogenesis of endometrial hyperplasia (EH). Mouse uteri and serum were collected from Tg2Rβ and normal littermates (NL), which were classified into three groups according to age. The incidence of EH increased in an age-dependent manner in both types of mice. However, in old age, Tg2Rβ mice showed more serious phenotypes of EH than NL. Immunohistochemical analysis revealed specific localization of IL2R β-chain in the glandular epithelial cells, with a correlation to the degree of EH, not only in the Tg2Rβ uteri but also in the NL uteri. Immunoreactions of CD3 and CD25 were detected in the uteri of Tg2Rβ but were weak in the uteri of NL, and CD25-positive cells were distributed in the endometrial stroma and myometrium in the Tg2Rβ mice. These findings suggest that the IL2R β-chain induces growth potential for glandular epithelial cells and an immune-privileged condition mediated by CD25+regulatory-T cells.
- 2009-06-01
著者
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OKADA Toshiya
Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of
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TAKESHITA Ai
Department of Integrated Structural Bioscience, Division of Veterinary Science, Graduate School of L
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KUSAKABE Ken
Department of Integrated Structural Bioscience, Division of Veterinary Science, Graduate School of L
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HONDO Eiichi
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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Shibata Masa‐aki
Department Of Anatomy And Cell Biology Division Of Life Sciences Osaka Medical College
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SHIBATA Masa-Aki
Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College
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OTSUKI Yoshinori
Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College
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KISO Yasuo
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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KATO Keiko
Department of Laboratory Animal Science, Division of Veterinary Science, Graduate School of Life and
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Kiso Yasuo
Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer
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Kiso Yasuo
Department Of Veterinary Anatomy Faculty Of Agriculture Yamaguchi University
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Kusakabe K
Department Of Laboratory Animal Science Division Of Veterinary Science Graduate School Of Life And E
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Kusakabe Ken
Department Of Anatomy And Biology Osaka Medical College
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Takeshita Ai
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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Okada T
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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岡田 利也
大阪府立大学
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Okada Toshiya
Department Of Veterinary Anatomy College Of Agriculture Osaka Prefecture University
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Okada T
Department Of Laboratory Animal Science Division Of Veterinary Science Graduate School Of Life And E
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Okada Toshiya
Department Of Integrated Structural Bioscience Division Of Veterinary Science Graduate School Of Lif
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Shibata Masa-aki
Department Of Anatomy And Cell Biology Division Of Life Sciences Osaka Medical College
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Otsuki Yoshinori
Department Of Anatomy And Cell Biology Division Of Life Sciences Osaka Medical College
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Otsuki Yoshinori
Department Of Anatomy & Biology Osaka Medical College
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Hondo Eiichi
Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer
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Hondo E
Yamaguchi Univ. Yamaguchi Jpn
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Kiso Y
Yamaguchi Univ. Yamaguchi Jpn
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Shibata Masa
Department Of Anatomy And Biology Osaka Medical College
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Otsuki Yoshinori
Osaka Medical Coll. Osaka Jpn
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Kato Keiko
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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Kokubu Keiji
The United Graduate School Of Veterinary Science Yamaguchi University
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Kato Keiko
Department Of Laboratory Animal Science Division Of Veterinary Science Graduate School Of Life And E
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Kato Keiko
Department Of Dermatology Kurume University School Of Medicine
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Hondo Eiichi
Department Of Veterinary Anatomy Yamaguchi University
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Kiso Yasuo
Laboratory Of Basic Veterinary Science The United Graduate School Of Veterinary Science Yamaguchi University
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Kato Keiko
Department Of Animal Medical Sciences Kyoto Sangyo University
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Takeshita Ai
Laboratory Of Laboratory Animal Science Division Of Veterinary Science Animal Science Graduate School Of Life And Environmental Science Osaka Prefecture University
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