Uterine Natural Killer Cells in Perforin and β_2-Microglobulin Deficient Mice(Anatomy)

概要

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Uterine natural killer (uNK) cells have roles for immune responses at the feto-maternal interface in mice. We studied the effects of β_2-microglobulin (β_2m) and perforin on proliferation and differentiation of uNK cells in pregnancy, using β_2-microglobulin-deficient (β_2m^<-/->) mice and perforin-deficient (P^<-/->) mice. The cell population of uNK cells in the metrial gland of P^<-/-> mice was tended to be higher than the control B6 mice. The cell population of uNK cells in the metrial gland of β_2m^<-/-> mice was significantly increased at Day 12 of pregnancy comparing to B6 and P^<-/-> mice. On the other hand, the cell population of uNK cells in the decidua basalis of β_2m^<-/-> mice was tended to be lower than B6 and P^<-/-> mice. These results indicate that β_2m may be involved in proliferation of uNK cells in the metrial gland, and that Am may affect the maturation of uNK cells in the decidua basalis.
社団法人日本獣医学会の論文
2009-02-25