ウシの卵胞におけるinhibin α-subunitのステージ特異的な分布と卵胞液中の各種ホルモンレベルについて

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概要

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• The changes in localization of inhibin α-subunit in bovine ovarian follicles during follicular development were assessed by immunohistochemical staining with monoclonal anti-inhibin α-subunit antibody. The changes in inhibin, estradiol-17β (E2), progesterone (P) and testosterone (T) levels in the follicular fluid during follicular development were also investigated. The follicles obtained from the bovine ovaries in mid-luteal stage were histologically classified into 7 stages. Stages I, II and III were growing healthy follicles, and stages IV, V, VI and VII were atretic follicles. In both growing and atretic follicles, inhibin α-subunit were histochemically demonstrated in the granulosa cells. Strong or moderate immunostaining for inhibin α-subunit were found only in the granulosa cells of stages II and III follicles (the strongest staining was found in stage III), and trace staining was seen in a small number of theca interna cells of stages II and III follicles. The granulosa cells of early atretic follicles (stage IV) also have the ability to produce and secrete inhibin, but finally they lost the ability. No positive staining was demonstrated in any cells of progressed atretic follicles (stage V, VI and VII). Inhibin level in the follicular fluid was higher in the growing follicles (highest level at stage II) than in the atretic follicles. Follicular fluid E2 level increased from stages I to III, but decreased from stage IV onward. The P levels remained low from stages I to VI, but increased only in stage VII. The T levels in stages III and VII were lower than in the other stages. Follicular fluid inhibin level were related to E2 level but not P or T levels. In conclusion, the inhibin α-subunit is produced by follicular granulosa cells in growing follicles of the bovine ovaries, and inhibin may stimulate E2 secretion in growing but not in atretic follicles.

• 日本繁殖生物学会の論文
• 1999-06-01

著者

• Kitamura Nobuo

  Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine

• HONDO Eiichi

  Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University

• 本道 栄一

  Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University

• Yamada Junzo

  Department Of Veterinary Anatomy Obihiro University Of Agriculture And Veterinary Medicine

• Manabe Noboru

  Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo

• Manabe Noboru

  Graduate School Of Agricultural And Life Sciences University Of Tokyo

• Manabe Noboru

  Unit Of Anatomy And Cell Biology Department Of Animal Sciences Kyoto University

• HASEGAWA Yoshihisa

  Laboratory Animal Science, Kitasato University, School of Veterinary Medicine and Animal Science, Ao

• MIYAMOTO AKIO

  Laboratory of Animal Genetics and Reproduction, Department of Animal Science, Obihiro University of

• Yamada Junzo

  Department Of Veterinary Anatomy Faculty Of Veterinary Medicine Hokkaido University

• Manabe Noboru

  Animal Resource Science Center The University Of Tokyo

• Hondo Eiichi

  Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer

• Kitamura Nobuo

  Department Of Cardiovascular And Thoracic Surgery Kyoto Prefectural University Of Medicine

• Manabe Noboru

  Animal Resource Sci. Center Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo

• Hondo E

  Yamaguchi Univ. Yamaguchi Jpn

• Yoshimura Shuichi

  Department of Veterinary Anatomy

• Murabayashi Hiroshi

  Department of Veterinary Anatomy

• Kitamura N

  Department Of Veterinary Anatomy Obihiro University Of Agriculture And Veterinary Medicine

• Miyamoto Akio

  Laboratory Of Animal Genefics And Reproduction Obihiro University Of Agriculture And Veterinary Medi

• Hasegawa Yoshihisa

  Laboratory Of Experimental Animals Faculty Of Veterinary Medicine And Animal Sciences University Of

• Hasegawa Yoshihisa

  Laboratory Animal Science Kitasato University School Of Veterinary Medicine And Animal Science

• Yamada J

  Obihiro Univ. Agriculture&veterinary Medicine Obihiro Jpn

• Miyamoto Akio

  Laboratory Of Animal Genetics And Reproduction Obihiro University Of Agriculture And Veterinary Medi

• Yoshimura Shuichi

  Department Of Veterinary Anatomy Obihiro University Of Agriculture And Veterinary Medicine

• Murabayashi Hiroshi

  Department Of Veterinary Anatomy Obihiro University Of Agriculture And Veterinary Medicine

• Hondo Eiichi

  Department Of Veterinary Anatomy Yamaguchi University

• 吉村 修一

  Department of Veterinary Anatomy, Obihiro University of Agriculture and Veterinary Medicine

• 村林 宏

  Department of Veterinary Anatomy, Obihiro University of Agriculture and Veterinary Medicine

• KITAMURA Nobuo

  Department of Agricultural Chemistry, The University of Tokyo

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