IL-2レセプターβ鎖過剰発現遺伝子改変マウスにおける子宮NK細胞の微細構造
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概要
- 論文の詳細を見る
We previously reported that all fetuses died or were resorbed on day 12 of pregnancy (Day 1=the day of plug) in interleukin-2 (IL-2) receptor β-chain overexpressed transgenic (Tg2Rβ) mice. In this study, to clarify the role of uterine natural killer (uNK) cells in pregnancy, the ultrastructure of Tg2Rβ mouse uNK cells was analyzed using a transmission electron microscope. uNK cells and their granules on day 10 of pregnancy were larger in Tg2Rβ mice than control mice, indicating that differentiation of uNK cells in Tg2Rβ mice progressed rapidly. Additionally, the granules of uNK cells in Tg2Rβ mice on day 10 of pregnancy had an irregular morphology. The multivesicular regions were present in the cap structure of these granules, suggesting that the uNK cells of the Tg2Rβ mice had cytotoxic activity.
- 日本繁殖生物学会の論文
著者
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Kusakabe Ken
Department Of Anatomy And Biology Osaka Medical College
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HONDO Eiichi
The United Graduate School of Veterinary Science, Faculty of Agriculture, Yamaguchi University
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KISO Yasuo
The United Graduate School of Veterinary Science, Faculty of Agriculture, Yamaguchi University
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KOKUBU Keiji
The United Graduate School of Veterinary Science, Yamaguchi University
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NAMBA Yasuharu
The United Graduate School of Veterinary Science, Yamaguchi University
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Sagara Eiji
Animal Research Center Kyushu Dental College
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Kokubu Keiji
The United Graduate School Of Veterinary Science Yamaguchi University
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國分 啓司
The United Graduate School of Veterinary Science, Yamaguchi University
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KISO Yasuo
The United Graduate School of Veterinary Science, Yamaguchi University
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本道 栄一
The United Graduate School of Veterinary Science, Yamaguchi University
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難波 泰治
The United Graduate School of Veterinary Science, Yamaguchi University
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