Agrin Pathway is Controlled by Leukemia Inhibitory Factor (LIF) in Murine Implantation
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概要
- 論文の詳細を見る
Agrin is the heparan sulfate proteoglycan (HSPG) that is well known as the molecule that aggregates acetylcholine receptor (AChR) through muscle specific kinase (MuSK) and rapsyn at neuromuscular junctions. HSPGs are spatiotemporally expressed in embryonic and maternal tissues during implantation. The present study examined the role of agrin in the mouse embryo using leukemia inhibitory factor (LIF)-deficient mice, which show complete sterility. Agrin was detected widely in the cytoplasm of uterine luminal epithelial cells at the third day of pregnancy (Day 3) and Day 4. At Day 5, agrin moved to the apical surface of the luminal epithelium. This migration was not found in LIF-deficient mice. AChR was also found in the apical surface of the uterine epithelium at Day 4 and Day 5 in normal mice. LIF-deficient mice did not show this pattern of expression. Only nAChR β1 subunit mRNA was increased at Day 5 in normal mice. Furthermore, acetylcholinesterase was active in the uterine stroma of normal mice throughout the implantation period and was exclusively active in the uterine epithelium at Day 4. Taken together, agrin signaling was activated in the uterus during embryo implantation in the mice. Here, we suggest that the agrin pathway is involved in closure of the uterine epithelium toward placentation.
- 日本繁殖生物学会の論文
- 2009-06-01
著者
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SUGIYAMA Makoto
Department of Radiology, Hokuriku Hospital
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HONDO Eiichi
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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KISO Yasuo
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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Kiso Yasuo
Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer
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Kiso Yasuo
Department Of Veterinary Anatomy Faculty Of Agriculture Yamaguchi University
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Stewart Colin
Institute Of Medical Biology
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Sugiyama Makoto
Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer
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Sugiyama Makoto
Department Of Radiology Hokuriku Hospital
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Hondo Eiichi
Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer
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Hondo E
Yamaguchi Univ. Yamaguchi Jpn
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Kiso Y
Yamaguchi Univ. Yamaguchi Jpn
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TERAKAWA Jumpei
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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WAKITANI Shoichi
Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi Univ
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Terakawa Jumpei
Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer
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Wakitani Shoichi
Laboratory Of Basic Veterinary Science United Graduate School Of Veterinary Science Yamaguchi Univer
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Sugiyama Makoto
Department Of Biotechnology Faculty Of Engineering Nagoya University
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Hondo Eiichi
Department Of Veterinary Anatomy Yamaguchi University
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Kiso Yasuo
Laboratory Of Basic Veterinary Science The United Graduate School Of Veterinary Science Yamaguchi University
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Wakitani Shoichi
Laboratory Of Basic Veterinary Science The United Graduate School Of Veterinary Science Yamaguchi University
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