Effects of anticonvulsants on the electroconvulsive threshold lowered by DA, 5-HT or GABA depletion.
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概要
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A cannula was chronically implanted in the rat ventriculus, and anticonvulsants were administered through the cannula. The effects of the anticonvulsants applied, intraventricully, were investigated on the decreased electroconvulsive threshold induced by pretreatment with α-methyl-p-tyrosine (α-MT), p-chlorophenylalanine (PCPA) or allylglycine. The TRH analog, DN-1417, valproate (VPA), and Phenobarbital (PB) raised the electroconvulsive threshold which had been lowered by a-MT. The reduced electroconvulsive threshold from PCPA was raised by DN-1417, but not by VPA or PB. The allylglycine induced lowering of the electroconvulsive threshold was raised by VPA and PB, but not by DN-1417. Phenytoin had no anticonvulsant effect on rats pretreated with these drugs. From these results, it was concluded that the anticonvulsant action of DN-1417 could be due to enhancement of dopamine and/or serotonin turnover.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Yamada Shigeto
Institute Of Brain Diseases Kurume University School Of Medicine
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Nakamura Jun
Department Of Environmental Sciences And Engineering University Of North Carolina
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MINE KOUICHIRO
Department of Neuropsychiatry, Kurume University School of Medicine
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