Comparison of the effects of benzodiazepine and nonbenzodiazepine anxiolytics on mouse-killing behavior in rats.
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概要
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The present study investigated the effects of nonbenzodiazepine anxiolytics on mouse-killing behavior in rats, compared with the effects of benzodiazepine anxiolytics. Mouse-killing behavior was induced by bilateral olfactory bulbectomy. The following drugs were administered 1ntraperitonea Ily: chlord 1azepoxide, diazepam, ethyl loflazepate, fludiazepam, zopiclone, suriclone, and CL 218, 872. Among these drugs, suriclone (ED50=1.3 mg/kg) and fludiazepam (ED50=5.9 mg/kg) showed potent suppressive effects. Diazepam, ethyl loflazepate, and CL 218, 872 showed only weak actions on mouse-killing behavior.
- 公益社団法人 日本薬理学会の論文
著者
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Ogawa Nobuya
Department Of Clinical Pharmacology Ehime University School Of Medicine
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OGAWA Nobuya
Department of Pharmacology, Ehime University School of Medicine
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YOSHIMURA Hiroyuki
Department of Pharmacology, Ehime University School of Medicine
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Yoshimura Hiroyuki
Department of Applied Chemistry, Faculty of Engineering, Kagoshima University
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TAKAOKA Nobuyuki
Department of Pharmacology, Ehime University School of Medicine
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