PROMOTION OF THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
スポンサーリンク
概要
- 論文の詳細を見る
The absorption of an immunosuppressive drug, cyclosporin A (CsA), with the aid of lipid-surfactant mixed micelles from the rat gastrointestinal (GI) tract and lymphatic delivery were studied. The administration of CsA in oily solution, sesame oil or linolic acid, into the rat duodenum indicated a small amount of CsA both in the plasma and lymph for about 6 h. the administration of CsA in the mixed micellar solution composing of linolic acid and HCO-60,polyoxyethylated (60 mol) hydrogenated castor oil, accelerated the absorption of CsA from the GI tract, and CsA was delivered into the lymphatics with an extremely high selectivity.
- 社団法人日本薬学会の論文
著者
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TAKADA Kanji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Shibata Nobuhito
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Womens College of Liber
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Yoshikawa Hiroshi
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Yoshikawa H
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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MURANISHI Shozo
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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MASUDA YOSHITO
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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YOSHIMURA HIROYUKI
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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OKA TAKAHIRO
Second Department of Surgery, Kyoto Prefectural University of Medicine
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Ono Takeshi
Hospital Pharmacy Shiga University Of Medical Science
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Takada Kanji
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Takada K
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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MASUDA Yasusuke
Department of Toxicology, Niigata College of Pharmacy
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Tatsumi T
Kyoto Univ. Kyoto Jpn
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Takada Kanji
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Oka Takahiro
Second Department Of Surgery Kyoto Prefectural University Of Medicine
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Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Masuda Y
Department Of Toxicology Niigata College Of Pharmacy
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MASUDA YOSHINOBU
Department of Pharmacology, Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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Tatsumi T
Department Of Physics Kyoto University
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Shibata Nobuhito
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Yoshimura Hiroyuki
Department Of Behavioral Pharmacology Ehime University School Of Medicine
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Yoshikawa Hiroshi
Department of Applied Physics, Handai Frontier Research Center, and Venture Business Laboratory of Center for Advanced Science and Innovation, Osaka University, Suita, Osaka 565-0871, Japan
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Shibata Nobuhito
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts
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Yoshimura Hiroyuki
Department of Applied Chemistry, Faculty of Engineering, Kagoshima University
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