POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY LIPID-SURFACTANT MIXED MICELLES I. IN VIVO AND TUMORNEUTRALIZING ACTIVITY AGAINST MOUSE ETHRLICH ASCITES TUMOR AND RAT ASCITES HEPATOMA AH66
スポンサーリンク
概要
- 論文の詳細を見る
Mixed micelles (MM) composed of polyoxyethylated (60 mol) hydrogenated castor oil (HCO60) as a harmless surfactant and linoleic acid (LA) as an essential fatty acid potentiated the antitumor activity of bleomycin (BLM). In the in vivo experiment, intraperitoneal administration of BLM with MM significantly prolonged the survival time of male ddY mice bearing Ehrlich ascites tumor and male Donryu rats bearing ascites hepatomas AH 66 inoculated intraperitoneally, compared with that of animals treated with BLM alone, BLM with HCO60,and BLM with LA, respectively, wheares MM had no antitumor effect to both tumors. Also in Winn-type tumor-neutralizing assay in which 10 male ddY mice were innoculated intraperitoneally with Ehrlich ascites tumor cells preincubated with a test material, BLM with showed a more marked enhancing activity with 3 surviving tumorfree mice than did BLM alone.
- 社団法人日本薬学会の論文
著者
-
TAKADA Kanji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
-
Yoshikawa Hiroshi
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
-
Yoshikawa H
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
-
MURANISHI Shozo
Department of Biopharmaceutics, Kyoto Pharmaceutical University
-
Takada Kanji
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
-
Takada K
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
-
Tatsumi T
Kyoto Univ. Kyoto Jpn
-
Takada Kanji
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
-
Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
-
Tatsumi T
Department Of Physics Kyoto University
-
Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
-
Muranishi Shozo
Department Of Biopharmaceutics Kyoto Pharmaceutical University
-
Yoshikawa Hiroshi
Department of Applied Physics, Handai Frontier Research Center, and Venture Business Laboratory of Center for Advanced Science and Innovation, Osaka University, Suita, Osaka 565-0871, Japan
関連論文
- Self-Dissolving Micropile Array Chip as Percutaneous Delivery System of Protein Drug
- Pharmacokinetics of Human Immunodeficiency Virus Protease Inhibitor, Nelfinavir, in Poloxamer 407-Induced Hyperlipidemic Model Rats(Biopharmacy)
- 1aSC-10 K凝縮下のニュートリノ不透明度と中性子星の進化
- 29p-YN-12 K中間子凝縮中での緩和過程におけるK中間子の熱励起効果
- 31a-YA-4 Κ中間子凝縮における緩和過程と中性子星の進化
- Application of Polyglycolized Glycerides in Protection of Amorphous Form of Etoricoxib during Compression
- 28pSJ-10 高密度核物質中の A 励起を取り入れた K 中間子自己エネルギーの解析的性質と分散関係(ハドロン物質・クォーク物質, 理論核物理)
- 30p-SC-12 中性子星に於けるK中間子凝縮相転移とガンマ線バースト
- 28a-SB-4 K中間子の媒質変化におけるベクトル型相互作用の役割
- Kaon Condensation and Neutron Stars〔邦文〕 (K中間子-核子相互作用とK中間子凝縮)
- 31a-W-12 K中間子凝縮のモデル依存性 II
- Utility of Nano-Sized, Water-in-Oil Emulsion as a Sustained Release Formulation of Glycyrrhizin
- Pharmacokinetics of FK-506,a Novel Immunosuppressant, after Intravenous and Oral Administrations to Rats
- Biological and Pharmaceutical Factors Affecting the Absorption and Lymphatic Delivery of Ciclosporin A from Gastrointestinal Tract
- STUDIES ON THE PROMOTING EFFECT OF LIPID-SURFACTANT MIXED MICELLES (MM) ON INTESTINAL ABSORPTION OF COLLOIDAL PARTICLES. DEPENDENCE ON PARTICLE SIZE AND ADMINISTRATION SITE
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY FUSOGENIC LIPID AS A MEMBRANE MODIFIER
- THE MODE OF ENHANCED ENTERAL ABSORPTION OF MACROMOLECULES BY LIPID-SURFACTANT MIXED MICELLES I
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY FUSOGENIC LIPID-SURFACTANT MIXED MICELLES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS A POORLY ABBSORBABLE DRUG. III.^ HISTOLOGICAL STUDY AFTER ADDITION OF VARIOUS ABSORPTION PROMOTERS IN RATS
- EFFECT OF ADMINISTRATION ROUTE ON THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS POORLY ABSORBABLE DRUGS. II. STUDY ON THE ABSORPTION PROMOTING EFFECT OF AZONE
- ROLE OF THE DISPERSION SYSTEMS CONTAINING FUSOGENIC LIPIDS ON ENHANCED ABSORPTION OF POORLY ABSORBABLE DRUGS FROM THE GASTROINTESTINAL TRACT
- PROMOTION OF THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY LIPID-SURFACTANT MIXED MICELLES I. IN VIVO AND TUMORNEUTRALIZING ACTIVITY AGAINST MOUSE ETHRLICH ASCITES TUMOR AND RAT ASCITES HEPATOMA AH66
- COMPARISON OF DISAPPEARANCE FROM BLOOD AND LYMPHATIC DELIVERY OF HUMAN FIBROBLAST INTERFERON IN RAT BY DIFFERENT ADMINISTRATION ROUTES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS POORLY ABSORBABLE DRUGS. I. COMPARISON OF PLASMA LEVELS AFTER ADDITION OF VARIOUS ABSORPTION PROMOTERS IN RAT
- OPTIMAL DOSAGE REGIMEN CALCULATION BASED ON THE REMAINING DRUG CONCENTRATIONS IN PLASMA
- INTESTINAL ABSORPTION OF CARBOXYFLUORESCEIN ENTRAPPED IN LIPOSOMES IN COMPARISON WITH ITS ADMINISTRATION WITH LIPID-SURFACTANT MIXED MICELLES
- A METHOD TO POTENTIATE ENTERAL ABSORPTION OF INTERFERON AND SELECTIVE DELIVERY INTO LYMPHATICS
- MOLECULAR WIGHT DEPENDENCE OF PERMSELECTIVITY TO RAT SMALL INTESTINAL BLOOD-LYMPH BARRIER FOR EXOGENOUS MACROMOLECULES ABSORBED FROM LUMEN
- PHARMACOKINETIC PROPERTY OF HUMAN INTERFERON AFTER ADMINISTRATION BY DIFFERENT ROUTES : PROMOTION OF INTESTINAL ABSORPTION AND SPECIFIC TRANSFER INTO LYMPHATICS
- Fast Computation of Fresnel Holograms Employing Difference
- Computer Generated Rainbow Hologram
- Charge Screening Effect in the Hadron-Quark Mixed Phase (Nuclear Physics)
- Structured Mixed Phase in Kaon Condensation(Proceedings of the YITP Workshop on Nuclear Matter under Extreme Conditions)
- Evaluation of Gastrointestinal Transit Characteristics of Oral Patch Preparation Using Caffeine as a Model Drug in Human Volunteers
- STUDY ON CIRCARDIAN AND DAY TO DAY VARIATION OF SVPCs AND THE EFFECT OF EXERCISE ON THE FREQUENCY OF SVPCs : Arrhythmias (I) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Pharmaceutical Approach to HIV Protease Inhibitor Atazanavir for Bioavailability Enhancement Based on Solid Dispersion System(Biopharmacy)
- -1032-COMPARISON OF SENSITIVITY OF 2-LEAD HOLTER ECG IN THE DETECTION OF ISCHEMICST DEPRESSIONS BETWEEN DAILY ACTIVITY AND EXERCISE TESTING : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Therapeutic Effectiveness and Plasma Levels of Single or Combination Use of Class I Antiarrhythmic Agents for Ventricular Arrhythmias : SYMPOSIUM ON HIGH RISK ARRHYTHMIA ITS MECHANISM AND TREATMENT : 51th Annual Scientific Session of the Japanese Circulat
- -53- COMPARISON OF THE PROGNOSIS OF VEN-TRICULAR TACHYCARDIA BETWEEN PATIENTS WITH AND WITHOUT ORGANIC HEART DISEASE : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- AN INNOVATIVE TECHNIQUE FOR RECORDING A 3-LEAD ELECTROCARDIOGRAM USING A 2-CHANNEL HOLTER RECORDER : Electrocardiography : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Changes in Electrophysiological Properties of Rat Skin with Age
- Preparation and Rectal Absorption of Highly Concentrated Glycyrrhizin Solution(Biopharmacy)
- 28a-R-8 媒質中のΚ中間子からのダイレプトン生成率
- A Case of Iris Melanocytoma Transformed to Malignant Melanoma
- Evaluation of Factors to Decrease Bioavailability of Cyclosporin A in Rats with Gentamicin-Induced Acute Renal Failure (Biopharmacy)
- Effect of Indinavir on the Intestinal Exsorption of Amprenavir, Saquinavir and Nelfinavir after Intravenous Administration in Rats
- Simultaneous determination of glucocorticoids in plasma or urine by high-performance liquid chromatography with precolumn fluorimetric derivatization by 9-anthroyl nitrile
- Evaluation of Factors to Decrease Plasma Concentration of an HIV Protease Inhibitor, Saquinavir in Ethanol-Treated Rats(Biopharmacy)
- Highly sensitive quantification of vancomycin in plasma samples using liquid chromatography-tandem mass spectrometry and oral bioavailability in rats
- Relationship between Excretion Clearance of Rhodamine 123 and P-Glycoprotein (Pgp) Expression Induced by Representative Pgp Inducers(Biopharmacy)
- In Vivo Effects of Cyclosporin A and Ketoconazole on the Pharmacokinetics of Representative Substrates for P-Glycoprotein and Cytochrome P450 (CYP) 3A in Rats(Biopharmacy)
- Effect of Chronic Administration of Ritonavir on Function of Cytochrome P450 3A and P-Glycoprotein in Rats(Biopharmacy)
- CONTRIBUTION OF SH-PROTEINS TO PROMOTIVE TRANSMUCOSAL PERMEATION OF POORLY ABSORBABLE DYE WITH OLEATE IN RAT COLON
- Clinical Pharmacokinetics of Mycophenolate Mofetil in Japanese Renal Transplant Recipients : a Retrospective Cohort Study in a Single Center(Biopharmacy)
- Neutrino Interactions in Octet Baryon Matter
- Chapter X Outlook
- Chapter VIII Implications of Various Hadron Phases to Neutron Star Phenomena
- Chapter VII Neutral Pion Condensation in Hot and Dense Nuclear Matter
- Chapter VI A Chiral Symmetry Approach to Meson Condensations
- Chapter V Toward Realistic Treatment of Neutral Pion-Condensed State
- Chapter III Characteristic Aspects of Pion-Condensed Phases
- A Chiral-Bag Approach to Static Interaction between Two Baryons : A Numerical Study with Use of the Finite Element Method : Nuclear Physics
- Static Interaction between Two Spherical Chiral Bags
- Continuous Decolorization of Molasses Waste Water Using Immobilized Lactobacillus hilgardii Cells(Microbiology & Fermentation Industry)
- Screening of Anaerobic Bacteria with the Ability to Decolorize Molasses Melanoidin(Microbiology & Fermentation Industry)
- Interaction between Two Quark Layers in Chiral Bag Model : Nuclear Physics
- Extra Neutrino Emissivity of Neutron Stars under the Combined Condensation of Neutral and charged Pions
- Neutral Pion Condensation and Alternating Layer Spin Model Including Isobar Δ(1232) in Hot Symmetric Nuclear Matter
- クォーク星のきらめき
- 超強磁場星における磁場の起源
- 高密度核物質での相転移と中性子星 (特集 物質とは何か--クォークがひらく新しい物質観)
- Permeation Enhancement of Ascorbic Acid by Self-Dissolving Micropile Array Tip through Rat Skin
- Self-Dissolving Micropiles for the Percutaneous Absorption of Recombinant Human Growth Hormone in Rats(Biopharmacy)
- Long-Term Pharmacokinetic Efficacy and Safety of Low-Dose Ritonavir as a Booster and Atazanavir Pharmaceutical Formulation Based on Solid Dispersion System in Rats(Biopharmacy)
- Antihyperglycemic Effect of Insulin from Self-Dissolving Micropiles in Dogs
- Effect of Water Intake on Pharmacokinetics of Lansoprazole from Fast Disintegrating Tablet in Human Subjects
- Bioadhesive Delivery of Metformin Using Prosopis Gum with Antidiabetic Potential
- Studies on the Intestinal Absorption of Low Molecular Weight Heparin Using Saturated Fatty Acids and Their Derivatives as an Absorption Enhancer in Rats (Pharmacology)
- Evaluation of Antiarrhythmic Drug Efficacy using Holter Electrocardiographic Technique : SYMPOSIUM ON INDICATION AND SELECTION OF ANTIARRHYTHMIC TREATMENT
- Bioequivalence study and evaluation study for absorption from oral cavity of lansoprazole fast disintegrating tablet in healthy subjects
- Purification and Properties of Membrane-bound Sulfite Dehydrogenase from Thiobacillus thiooxidans JCM7814
- SEM Imaging of Single Heavy Meromyosin Molecules on Hydrophilic Silicon Surface
- Effect of pH, Dietary Proteins and Trypsin Inhibitors on the Hydrolytic Rate of Human Granulocyte Colony-Stimulating Factor (G-CSF) by Rat Digestive Enzymes
- Absorption of Oligodeoxynucleotide by Suppository from Rat Rectal Route
- Evaluation of Carbamazepine Pharmacokinetic Profiles in Mice with Kainic Acid-Induced Acute Seizures(Miscellaneous)
- Effect of Glycerol-Induced Acute Renal Failure on the Pharmacokinetics of Lidocaine after Transdermal Application in Rats(Biopharmacy)
- Evaluation of Gastrointestinal Mucoadhesive Patch System (GI-MAPS) Containing Caffeine as a Model Drug in Human Volunteers
- COLON DELIVERY SYSTEM FOR PEPTIDE/PROTEIN DRUGS
- Effects of Diltiazem on Rheological Properties of Human Blood
- Ferromagnetism and Superconductivity in Quark Matter : Color Magnetic Superconductivity (Various phases in high density matter)
- Induction of Metallothionein-Like Cadmium-Binding Protein in the Testis by Oral Cadmium Administration in Rats
- Effects of Long-Term Cadmium Intake on Renal Function and Bone Mineral Density (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Purification and Properties of Thiosulfate Dehydrogenase from Acidithiobacillus thiooxidans JCM7814
- Increased Expression of Angiotensin-converting Enzyme in Retinas of Diabetic Rats
- Single-Particle Potential of Isobar Δ(1232) in Nuclear Matter Based on Extended Effective Interaction
- Pion Condensation and Alternating Layer Spin Model in Symmetric Nuclear Matter : Use of Extended Effective Nuclear Forces : Nuclear Physics
- A Chiral Bag Study of Quark Matter Confined in a Slab with Surrounding Pion Field : Particles and Fields
- One-Gluon-Exchange Effects and Stability of the Quark Alternating Layer Spin-Flavor Structure in High-Density Nuclear Matter : Nuclear Physics