Absorption of Oligodeoxynucleotide by Suppository from Rat Rectal Route
スポンサーリンク
概要
- 論文の詳細を見る
Rectal absorption of 32-mer phosphorothioate deoxynucleotides (S-Oligo) in the rat was attempted with the aid of a suppository containing oleic acid and a surfactant. Although, the suppository without adjuvant did not show detectable blood levels, that containing over 10% oleic acid enabled the absorption of S-Oligo with t_<max> at 2 h postdosing.
- 公益社団法人日本薬学会の論文
- 1997-10-15
著者
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TAKADA Kanji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Yoshikawa Hiroshi
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Takada Kanji
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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GOULD Franz
Max-Planck-Institut fur Experimentelle Medizin
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SEEBACH Stephen
Max-Planck-Institut fur Experimentelle Medizin
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Seebach S
Max-planck-institut Fur Experimentelle Medizin
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Yoshikawa Hiroshi
Department Of Drug Dosage Form Design Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace
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Yoshikawa Hiroshi
Department of Applied Physics, Handai Frontier Research Center, and Venture Business Laboratory of Center for Advanced Science and Innovation, Osaka University, Suita, Osaka 565-0871, Japan
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