Clinical Pharmacokinetics of Mycophenolate Mofetil in Japanese Renal Transplant Recipients : a Retrospective Cohort Study in a Single Center(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Mycophenolate mofetil (MMF), a morpholinoethyl ester of mycophenolic acid (MPA), is currently widely used in organ transplantation as an immunosuppressant. The usefulness of therapeutic drug monitoring (TDM) of MPA after MMF dosing is not clear in Japanese renal transplant patients. In this study, to obtain more information for TDM of MPA, the association between MPA pharmacokinetic characteristics and the development of the side effects, and the effect of other concomitant immunosupressants such as cyclospoline A (CyA), tacrolimus (FK) and predonisolone (PSL) on MPA pharmacokinetics were investigated in detail. Moreover, the effects of enterohepatic recirculation (EHRA) on pharmacokinetic characteristics of MPA and the development of the side effects were also investigated. AUC^<0-9>_<MPA> with FK medication was 1.3-1.9 times higher than that with CyA medication, and the contribution to the plasma level of MPA of FK might be smaller than that of CyA, because EHRA inhibition by CyA was 2 times greater than that by FK. AUC^<0-9>_<MPA> was not influenced by PSL. The association between AUC^<0-9>_<MPA> and the development of the side effects was not observed; however, the development of side effects (leukopenia and diarrhea) in the EHRA group was 2 times higher than that in the non-EHRA group. These results suggested that TDM for MPA after MMF dosing was desirable in Japanease transplant patients. However, though not frequently, AUC obtained by multiple blood sampling after MMF dosing was needed. In addition, EHRA has led to increasing interest in MMF medication.
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
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SUGIOKA Nobuyuki
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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TAKADA Kanji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Shibata Nobuhito
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Womens College of Liber
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OKAMOTO Masahiko
Department of Radiation Oncology, Gunma University Graduate School of Medicine
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YOSHIMURA NORIO
Department of Organ Transplant and Endoclinological Surgery, Kyoto Prefectural University of Medicin
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Takada Kanji
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Takada K
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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ITO Yukako
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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SASAKI Takayuki
Department of Surgery, Shinshu University School of Medicine
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Takada Kanji
Department Of Biopharmaceutics Kyoto Pharmaceutical University:exploratory Development Laboratories
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Sugioka Nobuyuki
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Okamoto Masahiko
Department Of Transplantation And Regenerative Surgery Kyoto Prefectural University Of Medicine
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KOKUHU Takatoshi
Department of Hospital Pharmacy, Kyoto Prefectural University of Medicine
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Kokuhu Takatoshi
Department Of Hospital Pharmacy Kyoto Prefectural University Of Medicine
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Yoshimura Norio
Department Of Organ Transplant And Regenerative Surgery Kyoto Prefectural University Of Medicine Gra
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Shibata Nobuhito
Dep. Of Pharmacokinetics Kyoto Pharmaceutical Univ.
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Okamoto Masahiko
Department Of Cardiovascular Surgery Kawasaki Municipal Hospital
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Sasaki Takayuki
Department Of Nuclear Engineering Kyoto University
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Sasaki Takayuki
Department Of Hospital Pharmacy Kyoto Prefectural University Of Medicine
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Sasaki Takayuki
Department Of Biology Faculty Of Science Niigata University
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Yoshimura Norio
Department Of Organ Transplant And Regenerative Surgery Kyoto Prefectural University Of Medicine Graduate School Of Medical Science
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Inoue Yuji
Department of Pharmacokinetics, Kyoto Pharmaceutical University
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Shibata Nobuhito
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts
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ITO Yukako
Department of Dermatology and Plastic Surgery, Head & Neck Surgery
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