STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IgG BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. V. MECHANISM OF ANTI-INFLAMMATORY ACTION OF CARBOXAMIDE-METHYLATED L-CHAIN (Fr. I-L) AND H-CHAIN (Fr. I-H) FROM HUMAN SERUM IgG.

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Using the xylene ear method in mice, it was demonstrated that the reduced and carboxamide-methylated fragments of human serum IgG (Fr. I-H and Fr. I-L) significantly suppressed capillary permeability. It was also shown that leucocyte emigration and protein leakage into and esterase activity of the pouch fluid, which was accumulated by carboxymethyl cellulose injections, were suppressed by the administration of the fragments. Moreover, the lipid peroxide level was lowered by both Fr. I-H and Fr. I-L in the liver of either carrageenin-induced, paw edema-bearing or kaolin pouch inflammation in rats. The facts obtained in this study indicated the mechanisms of the antiinflammatory effects of Fr. I-H and Fr. I-L were mainly caused by both the inhibitory effect on leucocyte emigration into the site of injury and stabilization of the membrane by inhibiting lipid peroxidation of the inflammatory tissue.
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