Studies on Thermophile Products. VII. Effect of 1,3-Di-14-methylpentadecanoyl Glycerol and Its Related Isofatty Acids on T Cell Proliferation in Vitro

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概要

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• It has been found that Bacillus stearothermophilus UK563-derived immunosuppressant fraction (Fr. 5-B) consists of 1,3-diacylglycerols with saturated iso- and anteiso-type fatty acids (C_<14 : 0>-C_<18 : 0>) as major components. The compound, 1,3-di-14-methylpentadecanoyl glycerol (1,3-diiso C_<16 : 0> G), was synthesized and its effect on T cell proliferation was investigated together with its related isofatty acids. While 1,3-diiso C_<16 : 0> G, iso C_<16 : 0>, iso C_<17 : 0>, iso C_<17 : 0>methyl ester (OMe) and anteiso C_<17 : 0> OMe suppressed the mixed lymphocyte reaction (MLR) of C57BL/6 against BALB/c mice, iso C_<15 : 0>, 1,3-acylglycerols with normal C_<16 : 0>, C_<16 : 1> and C_<18 : 0> did not, suggesting that the presence of isofatty acids with a certain chain length may be essential for the suppression of MLR. 1,3-Diiso C_<16 : 0> G and iso C_<16 : 0> strongly inhibited the autologous MLR of mesenteric lymph node cells against self-antigen presenting cells in MRL/MpJ-lpr/lpr (MRL/lpr) mice, but had no effect on concanavalin A-induced T cell proliferation.

• 社団法人日本薬学会の論文
• 1994-06-15

著者

• 稲田 昭

  Faculty of Pharmaceutical Sciences, Setsunan University

• 中西 勤

  Faculty of Pharmaceutical Sciences, Setsunan University

• 伊東 進

  阪大・薬

• 小濱 靖弘

  阪大薬

• 小濱 靖弘

  大阪大学 薬 微薬品化

• 小濱 靖弘

  Faculty of Pharmaceutical Sciences, Osaka University

• 刀根 秀樹

  Faculty of Pharmaceutical Sciences, Osaka University

• 高江 慎一

  Faculty of Pharmaceutical Sciences, Osaka University

• 三村 務

  Faculty of Pharmaceutical Sciences, Osaka University

• 田中 啓詞

  Faculty of Pharmaceutical Sciences, Osaka University

• 仙波 太郎

  Faculty of Pharmaceutical Sciences, Osaka University

• 伊東 進

  Faculty of Pharmaceutical Sciences, Osaka University

• 三村 務

  大阪大学薬学部

• 稲田 昭

  摂南大薬

• 中西 勤

  摂南大薬

• 田中 啓詞

  Faculty Of Pharmaceutical Sciences Osaka University

• 小浜 靖弘

  大阪大学薬学部

• 中西 勤

  摂南大学薬学部

• 稲田 昭

  摂南大学薬学部

• 中西 勤

  Faculty Of Pharmaceutical Sciences Osaka University

• Mimura T

  Osaka Univ. Osaka Jpn

• 仙波 太郎

  Faculty Of Pharmaceutical Sciences Osaka University

• 高江 慎一

  Faculty Of Pharmaceutical Sciences Osaka University

• Itoh S

  Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osada Univers

• 刀根 秀樹

  Faculty Of Pharmaceutical Sciences Osaka University

• Itoh S

  Showa Denko Co. Tokyo Jpn

• 稲田 昭

  Faculty Of Pharmaceutical Sciences Setsunan University

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